First total synthesis of dl-duocarmycin A

Yasumichi Fukuda; Kazuhiko Nakatani; Yoshio Ito; Shiro Terashima

doi:10.1016/S0040-4039(00)97151-X

First total synthesis of dl-duocarmycin A

Yasumichi Fukuda, Kazuhiko Nakatani, Yoshio Ito, Shiro Terashima

研究成果: Contribution to journal › Article › 査読

36 被引用数 (Scopus)

抄録

The title synthesis could be achieved by featuring introduction of a methoxycarbonyl group into the C-4 position of a 5-aminoindoline nucleus by way of an isatin derivative and subsequent ring closure to a methyl 2-methylindoxyl-2-carboxylate system by the Dieckmann cyclization.

本文言語	英語
ページ（範囲）	6699-6702
ページ数	4
ジャーナル	Tetrahedron Letters
巻	31
号	46
DOI	https://doi.org/10.1016/S0040-4039(00)97151-X
出版ステータス	出版済み - 1 1 1990
外部発表	はい

All Science Journal Classification (ASJC) codes

生化学
創薬
有機化学

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10.1016/S0040-4039(00)97151-X

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title = "First total synthesis of dl-duocarmycin A",

abstract = "The title synthesis could be achieved by featuring introduction of a methoxycarbonyl group into the C-4 position of a 5-aminoindoline nucleus by way of an isatin derivative and subsequent ring closure to a methyl 2-methylindoxyl-2-carboxylate system by the Dieckmann cyclization.",

author = "Yasumichi Fukuda and Kazuhiko Nakatani and Yoshio Ito and Shiro Terashima",

year = "1990",

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doi = "10.1016/S0040-4039(00)97151-X",

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T1 - First total synthesis of dl-duocarmycin A

AU - Fukuda, Yasumichi

AU - Nakatani, Kazuhiko

AU - Ito, Yoshio

AU - Terashima, Shiro

PY - 1990/1/1

Y1 - 1990/1/1

N2 - The title synthesis could be achieved by featuring introduction of a methoxycarbonyl group into the C-4 position of a 5-aminoindoline nucleus by way of an isatin derivative and subsequent ring closure to a methyl 2-methylindoxyl-2-carboxylate system by the Dieckmann cyclization.

AB - The title synthesis could be achieved by featuring introduction of a methoxycarbonyl group into the C-4 position of a 5-aminoindoline nucleus by way of an isatin derivative and subsequent ring closure to a methyl 2-methylindoxyl-2-carboxylate system by the Dieckmann cyclization.

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U2 - 10.1016/S0040-4039(00)97151-X

DO - 10.1016/S0040-4039(00)97151-X

M3 - Article

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VL - 31

SP - 6699

EP - 6702

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

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ER -

First total synthesis of dl-duocarmycin A

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