Five adult cases of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis

Yasunobu Abe, Motoaki Shiratsuchi, Eriko Nagasawa, Rie Ohtsuka, Junichi Kiyasu, Eriko Sada, Kensaku Idutsu, Kazuhiro Kotoh, Junji Nishimura, Shouichi Ohga, Ryoichi Takayanagi

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)

抄録

Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) is more common in children, and is characterized by pancytopenia, liver dysfunction and coagulopathy caused by interactions between EBV-infected T cells and activated macrophages. We describe here five adults with EBV-HLH. The median age was 17 years (range 16 approximately 40). HLH developed in 4 patients within 2 months after the primary infection, and in the other one during the reactivation. All patients had a high EBV viral load in peripheral blood (2 x 10(2)-3 x 10(6) copies/ml) and monoclonal proliferation of EBV-infected T cells. All patients received immunosuppressive therapy with or without etoposide, and two patients required plasmapheresis due to the severity. Three patients are alive in complete remission (follow up periods; 13, 19, 30 months), while two patients became refractory to chemo-immunotherapy and died despite multidrug chemotherapy. EBV-HLH should be more widely recognized in adults in order to achieve early diagnosis and appropriate treatment.

元の言語英語
ページ(範囲)74-79
ページ数6
ジャーナル[Rinshō ketsueki] The Japanese journal of clinical hematology
51
発行部数1
出版物ステータス出版済み - 1 2010

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Hemophagocytic Lymphohistiocytosis
Human Herpesvirus 4
T-Lymphocytes
Pancytopenia
Plasmapheresis
Etoposide
Immunosuppressive Agents
Viral Load
Immunotherapy
Liver Diseases
Early Diagnosis
Macrophages
Drug Therapy
Therapeutics
Infection

All Science Journal Classification (ASJC) codes

  • Medicine(all)

これを引用

Five adult cases of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis. / Abe, Yasunobu; Shiratsuchi, Motoaki; Nagasawa, Eriko; Ohtsuka, Rie; Kiyasu, Junichi; Sada, Eriko; Idutsu, Kensaku; Kotoh, Kazuhiro; Nishimura, Junji; Ohga, Shouichi; Takayanagi, Ryoichi.

:: [Rinshō ketsueki] The Japanese journal of clinical hematology, 巻 51, 番号 1, 01.2010, p. 74-79.

研究成果: ジャーナルへの寄稿記事

Abe, Y, Shiratsuchi, M, Nagasawa, E, Ohtsuka, R, Kiyasu, J, Sada, E, Idutsu, K, Kotoh, K, Nishimura, J, Ohga, S & Takayanagi, R 2010, 'Five adult cases of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis', [Rinshō ketsueki] The Japanese journal of clinical hematology, 巻. 51, 番号 1, pp. 74-79.
Abe, Yasunobu ; Shiratsuchi, Motoaki ; Nagasawa, Eriko ; Ohtsuka, Rie ; Kiyasu, Junichi ; Sada, Eriko ; Idutsu, Kensaku ; Kotoh, Kazuhiro ; Nishimura, Junji ; Ohga, Shouichi ; Takayanagi, Ryoichi. / Five adult cases of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis. :: [Rinshō ketsueki] The Japanese journal of clinical hematology. 2010 ; 巻 51, 番号 1. pp. 74-79.
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