Five-Year Changes in Cognitive Function and Their Predictor in Adult Moyamoya Disease

Akira Nakamizo, Toshiyuki Amano, Satoshi Matsuo, Yuichiro Miyamatsu, Takahiro Kuwashiro, Masahiro Yasaka, Yasushi Okada, Masahiro Mizoguchi, Koji Yoshimoto

研究成果: ジャーナルへの寄稿学術誌査読

抄録

Objective: The long-term outcomes of cognitive function in moyamoya disease remain unknown. We aimed to assess 5-year changes in cognitive function in adult moyamoya disease patients and to evaluate the value of the magnetic resonance angiography (MRA) steno-occlusive score to predict cognitive changes. Methods: Participants comprised 20 consecutive patients whose cognitive functions had been evaluated using the Frontal Assessment Battery (FAB) and Neurobehavioral Cognitive Status Examination (Cognistat) at baseline and reassessed 5 years later. Results: The total FAB score and total Cognistat score were lower after 5 years in 9 patients each. The Wilcoxon signed-rank test showed that subscores for conceptualization and comprehension increased, while subscores for mental flexibility, programming, and inhibitory control significantly decreased after 5 years. The right MRA total score and right posterior cerebral artery score were negatively associated with 5-year changes in the total FAB score and total Cognistat score. The right posterior cerebral artery score was significantly associated with changes in subscores for mental flexibility, programming, sensitivity to interference, and construction. Conclusions: Specific cognitive domains can decline over time in patients with adult moyamoya disease. MRA findings might be useful for predicting future declines in cognitive function.

本文言語英語
ジャーナルWorld Neurosurgery
DOI
出版ステータス印刷中 - 2022

!!!All Science Journal Classification (ASJC) codes

  • 外科
  • 臨床神経学

フィンガープリント

「Five-Year Changes in Cognitive Function and Their Predictor in Adult Moyamoya Disease」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル