Flavone-catalyzed apoptosis in Scutellaria baicalensis

Motosuke Hirunuma, Yoshinari Shoyama, Kaori Tabata, Seiichi Sakamoto, Futoshi Taura, Yukihiro Shoyama, Hiroyuki Tanaka, Satoshi Morimoto

研究成果: ジャーナルへの寄稿記事

12 引用 (Scopus)

抄録

In response to mechanical damage, roots of Scutellaria baicalensis undergo cell death within 24 h. The flavone baicalein was identified as the factor regulating apoptosis in the damaged roots of S. baicalensis. Plant apoptosis is known to be triggered by oxidative damage of DNA through oxidative bursts, whereas baicalein causes apoptosis in Scutellaria cells by a copper-dependent oxidation of nuclear DNA without inducing an oxidative burst. S. baicalensis possesses an interesting system for quickly producing this apoptosis-inducing flavone in its cells. Intact Scutellaria cells contain little baicalein but store a large amount of baicalin (baicalein 7-O-β-D-glucuronide). Stress treatment of Scutellaria cells immediately initiates hydrolysis of baicalin by endogenous β-glucuronidase, and the resulting baicalein is immediately translocated to the nucleus, leading to apoptosis. Thus, S. baicalensis possesses a unique apoptosis-inducing system that is linked with metabolism of baicalin.

元の言語英語
ページ(範囲)752-760
ページ数9
ジャーナルPhytochemistry
72
発行部数8
DOI
出版物ステータス出版済み - 6 1 2011

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flavone
Scutellaria baicalensis
flavones
Scutellaria
apoptosis
Apoptosis
Respiratory Burst
cells
mechanical damage
Glucuronidase
DNA
Glucuronides
Cell death
Metabolism
DNA damage
nuclear genome
DNA Damage
cell death
Copper
Hydrolysis

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture

これを引用

Flavone-catalyzed apoptosis in Scutellaria baicalensis. / Hirunuma, Motosuke; Shoyama, Yoshinari; Tabata, Kaori; Sakamoto, Seiichi; Taura, Futoshi; Shoyama, Yukihiro; Tanaka, Hiroyuki; Morimoto, Satoshi.

:: Phytochemistry, 巻 72, 番号 8, 01.06.2011, p. 752-760.

研究成果: ジャーナルへの寄稿記事

Hirunuma, Motosuke ; Shoyama, Yoshinari ; Tabata, Kaori ; Sakamoto, Seiichi ; Taura, Futoshi ; Shoyama, Yukihiro ; Tanaka, Hiroyuki ; Morimoto, Satoshi. / Flavone-catalyzed apoptosis in Scutellaria baicalensis. :: Phytochemistry. 2011 ; 巻 72, 番号 8. pp. 752-760.
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AU - Taura, Futoshi

AU - Shoyama, Yukihiro

AU - Tanaka, Hiroyuki

AU - Morimoto, Satoshi

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