TY - JOUR
T1 - Flavones suppress type I IL-4 receptor signaling by down-regulating the expression of common gamma chain
AU - Yamashita, Shuya
AU - Yamashita, Tatsunori
AU - Yamada, Koji
AU - Tachibana, Hirofumi
PY - 2010/2
Y1 - 2010/2
N2 - Immunoglobulin E (IgE) production is induced by interleukin (IL)-4 signaling mediated by type I IL-4 receptor (IL-4R) in B cells. We found that flavones inhibited IL-4-induced ε germline transcription which is essential for IgE class switching, and the phosphorylation of signal transducer and activator of transcription 6, janus kinase 3, and IL-4Rα, whereas IL-4 signaling mediated through type II IL-4R was unaffected by flavones. Furthermore, flavones reduced the expression of common gamma chain, a characteristic constituent subunit of type I IL-4R, suggesting that flavones suppress type I IL-4R signaling.
AB - Immunoglobulin E (IgE) production is induced by interleukin (IL)-4 signaling mediated by type I IL-4 receptor (IL-4R) in B cells. We found that flavones inhibited IL-4-induced ε germline transcription which is essential for IgE class switching, and the phosphorylation of signal transducer and activator of transcription 6, janus kinase 3, and IL-4Rα, whereas IL-4 signaling mediated through type II IL-4R was unaffected by flavones. Furthermore, flavones reduced the expression of common gamma chain, a characteristic constituent subunit of type I IL-4R, suggesting that flavones suppress type I IL-4R signaling.
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U2 - 10.1016/j.febslet.2009.12.044
DO - 10.1016/j.febslet.2009.12.044
M3 - Article
C2 - 20040389
AN - SCOPUS:77649270386
SN - 0014-5793
VL - 584
SP - 775
EP - 779
JO - FEBS Letters
JF - FEBS Letters
IS - 4
ER -