抄録
To characterize the differential and proliferative activities of FLK-1(+) cells derived from mouse fetal liver. The FLK-1(+) fraction were enriched from the fetal liver using immunomagnetic method and their differential and proliferative activities were examined in culture medium and in vivo via transplantation of FLK-1(+) cells into the inferior pole of the spleen of nine-week-old male C57 BL/6 mice after two-thirds hepatectomy. In response to growth factors, FLK-1(+) cells expressed typical lineage-specific markers for vascular endothelial cells, smooth muscle cells. Intrahepatic implantation of FLK-1(+) cells resulted in the formation of blood vessels in the fibrous capsule of partially hepatectomized liver. These results indicate that FLK-1(+) cells derived from mouse fetal liver could differentiate into endothelial cells and smooth muscle cells and they may serve as potential stem cells for clinical cell-based therapy.
本文言語 | 英語 |
---|---|
ページ(範囲) | 1108-1112 |
ページ数 | 5 |
ジャーナル | Zhonghua xin xue guan bing za zhi [Chinese journal of cardiovascular diseases] |
巻 | 38 |
号 | 12 |
出版ステータス | 出版済み - 12 1 2010 |
外部発表 | はい |
All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine