抄録
A concise procedure to prepare optically active (3R)- and (3S)-(E)-1-iodohexa-1,5-dien-3-ol was developed. Ethyl (E)-3-iodoacrylate was converted to racemic (E)-1-iodohexa-1,5-dien-3-ol under flow and batch conditions via successive half reduction followed by Grignard reaction. Kinetic resolution of the racemic alcohol was achieved under flow conditions by using lipase packed in a column to afford (3S)-(E)-1-iodohexa-1,5-dien-3-ol and corresponding (3R)-acetate. Removal of the acetyl group was also carried out under flow conditions by using ion exchange resin packed in a column and (3R)-(E)-1-iodohexa-1,5-dien-3-ol was obtained after simple evaporation of the eluent.
本文言語 | 英語 |
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ページ(範囲) | 1116-1118 |
ページ数 | 3 |
ジャーナル | Chemistry Letters |
巻 | 47 |
号 | 9 |
DOI | |
出版ステータス | 出版済み - 1 1 2018 |
All Science Journal Classification (ASJC) codes
- Chemistry(all)