Fluorescence-guided bone resection by using Visually Enhanced Lesion Scope in diffuse chronic sclerosingosteomyelitis of the mandible: Clinical and pathological evaluation

Daigo Yoshiga, Masaaki Sasaguri, Kou Matsuo, Sei Yoshida, Masataka Uehara, Manabu Habu, Kazuya Haraguchi, Tatsurou Tanaka, Yasuhiro Morimoto, Izumi Yoshioka, Kazuhiro Tominaga

研究成果: ジャーナルへの寄稿記事


Diffuse chronic sclerosingosteomyelitis (DCSO) is a refractory disease, becausethe etiology and pathogenesis remain poorly understood and to determine the border betweenunhealthy boneandhealthybone is difficult. However, progressive inflammation, clinical symptoms and a high recurrence rate of DCSO were the reasons for surgical treatment. We report a case of a 66-year old woman with DCSO of the right side of mandible who was treated with hemimandibulectomy and simultaneous reconstruction by vascularized free fibula flap. After preoperative administration of minocycline for 1 month, the bone fluorescence was successfully monitored by using a Visually Enhanced Lesion Scope (VELscope®). Intraoperatively, we could determine the resection boundaries. We investigated the clinical and histopathological findings. The fluorescence findings were well correlated with histopathological findings. Using a VELscope®was handy and useful to determine the border between DCSO lesion andhealthybone. The free fibula flap under the minocycline-derived bone fluorescence by using a VELscope®offered a good quality of mandibular bone and the successful management of an advanced and refractory DCSO.

ジャーナルJournal of Clinical and Experimental Dentistry
出版物ステータス出版済み - 1 1 2015


All Science Journal Classification (ASJC) codes

  • Dentistry(all)