Fluorescence tumor-imaging using a thermo-responsive molecule with an emissive aminoquinoline derivative

Takeru Araki, Yasufumi Fuchi, Shuhei Murayama, Ryoma Shiraishi, Tokimi Oyama, Mariko Aso, Ichio Aoki, Shigeki Kobayashi, Ken-Ichi Yamada, Satoru Karasawa

研究成果: ジャーナルへの寄稿記事

抄録

We synthesized (2,4-trifluoromethyl-7-N-bis(2,5,8,11-tetraoxatridecane-13-yl)-aminoquinoline) TFMAQ-diEg4, an emissive aminoquinoline derivative that incorporated two tetraethyleneglycol chains into an amino group. TFMAQ-diEg4 showed fluorescence and thermo-responsive properties accompanied by a lower critical solution temperature (LCST), due to the introduction of the oligoethylene glycol chain. This thermo-responsive LCST behavior occurred at the border of a cloud point. Below and above the cloud point, self-assemblies of 6-7-nm nanoparticles and ~2000-nm microparticles were observed, in vitro. In addition, TFMAQ-diEg4 showed a high solubility, over 20 mM for aqueous solution, in vivo, which not only prevented thrombosis but also allowed various examinations, such as single intravenous administration and intravenous drips. Intravenous administration of TFMAQ-diEg4, to tumor-bearing, mice led to the accumulation of the molecule in the tumor tissue, as observed by fluorescence imaging. A subset of mice was treated with local heat around their tumor tissue and an intravenous drip of TFMAQ-diEg4, which led to a high intensity of TFMAQ-diEg4 emission within the tumor tissue. Therefore, we revealed that TFMAQ-diEg4 was useful as a fluorescence probe with thermo-responsive properties.

元の言語英語
記事番号782
ジャーナルNanomaterials
8
発行部数10
DOI
出版物ステータス出版済み - 10 2 2018

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Aminoquinolines
Tumors
Fluorescence
Derivatives
Imaging techniques
Molecules
Tissue
Bearings (structural)
Glycols
Self assembly
Solubility
Nanoparticles
Temperature

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)
  • Materials Science(all)

これを引用

Fluorescence tumor-imaging using a thermo-responsive molecule with an emissive aminoquinoline derivative. / Araki, Takeru; Fuchi, Yasufumi; Murayama, Shuhei; Shiraishi, Ryoma; Oyama, Tokimi; Aso, Mariko; Aoki, Ichio; Kobayashi, Shigeki; Yamada, Ken-Ichi; Karasawa, Satoru.

:: Nanomaterials, 巻 8, 番号 10, 782, 02.10.2018.

研究成果: ジャーナルへの寄稿記事

Araki, T, Fuchi, Y, Murayama, S, Shiraishi, R, Oyama, T, Aso, M, Aoki, I, Kobayashi, S, Yamada, K-I & Karasawa, S 2018, 'Fluorescence tumor-imaging using a thermo-responsive molecule with an emissive aminoquinoline derivative', Nanomaterials, 巻. 8, 番号 10, 782. https://doi.org/10.3390/nano8100782
Araki, Takeru ; Fuchi, Yasufumi ; Murayama, Shuhei ; Shiraishi, Ryoma ; Oyama, Tokimi ; Aso, Mariko ; Aoki, Ichio ; Kobayashi, Shigeki ; Yamada, Ken-Ichi ; Karasawa, Satoru. / Fluorescence tumor-imaging using a thermo-responsive molecule with an emissive aminoquinoline derivative. :: Nanomaterials. 2018 ; 巻 8, 番号 10.
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abstract = "We synthesized (2,4-trifluoromethyl-7-N-bis(2,5,8,11-tetraoxatridecane-13-yl)-aminoquinoline) TFMAQ-diEg4, an emissive aminoquinoline derivative that incorporated two tetraethyleneglycol chains into an amino group. TFMAQ-diEg4 showed fluorescence and thermo-responsive properties accompanied by a lower critical solution temperature (LCST), due to the introduction of the oligoethylene glycol chain. This thermo-responsive LCST behavior occurred at the border of a cloud point. Below and above the cloud point, self-assemblies of 6-7-nm nanoparticles and ~2000-nm microparticles were observed, in vitro. In addition, TFMAQ-diEg4 showed a high solubility, over 20 mM for aqueous solution, in vivo, which not only prevented thrombosis but also allowed various examinations, such as single intravenous administration and intravenous drips. Intravenous administration of TFMAQ-diEg4, to tumor-bearing, mice led to the accumulation of the molecule in the tumor tissue, as observed by fluorescence imaging. A subset of mice was treated with local heat around their tumor tissue and an intravenous drip of TFMAQ-diEg4, which led to a high intensity of TFMAQ-diEg4 emission within the tumor tissue. Therefore, we revealed that TFMAQ-diEg4 was useful as a fluorescence probe with thermo-responsive properties.",
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AU - Oyama, Tokimi

AU - Aso, Mariko

AU - Aoki, Ichio

AU - Kobayashi, Shigeki

AU - Yamada, Ken-Ichi

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