Focal Adhesion Kinase in Cell-Material Interactions

Cristina González-García, Manuel Salmerón-Sánchez, Andrés J. García

研究成果: Chapter in Book/Report/Conference proceedingChapter

抜粋

This chapter presents a broad overview of the role of focal adhesion kinases (FAKs) in the cell-material interactions. It summarizes the effects that different material properties have on FAK signaling. The chapter first discusses the involvement of FAK in classical cellular processes at the material interface such as cell proliferation, cell migration, and mechanosensing responses. It, then reviews recent advances on the role of FAK in the generation of adhesive forces. Finally, the influence of material properties, such as chemical composition, surface nanotopography, and substrate stiffness, on FAK expression and phosphorylation is summarized, seeking to identify which surface properties trigger initial cell signaling at the material interface.

元の言語英語
ホスト出版物のタイトルPolymers in Regenerative Medicine
ホスト出版物のサブタイトルBiomedical Applications from Nano- to Macro-Structures
出版者wiley
ページ147-176
ページ数30
ISBN(電子版)9781118356692
ISBN(印刷物)9780470596388
DOI
出版物ステータス出版済み - 1 30 2014
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Engineering(all)
  • Chemical Engineering(all)
  • Materials Science(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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  • これを引用

    González-García, C., Salmerón-Sánchez, M., & García, A. J. (2014). Focal Adhesion Kinase in Cell-Material Interactions. : Polymers in Regenerative Medicine: Biomedical Applications from Nano- to Macro-Structures (pp. 147-176). wiley. https://doi.org/10.1002/9781118356692.ch4