Focal Adhesion Kinase in Cell-Material Interactions

Cristina González-García, Manuel Salmerón-Sánchez, Andrés J. García

研究成果: Chapter in Book/Report/Conference proceedingChapter


This chapter presents a broad overview of the role of focal adhesion kinases (FAKs) in the cell-material interactions. It summarizes the effects that different material properties have on FAK signaling. The chapter first discusses the involvement of FAK in classical cellular processes at the material interface such as cell proliferation, cell migration, and mechanosensing responses. It, then reviews recent advances on the role of FAK in the generation of adhesive forces. Finally, the influence of material properties, such as chemical composition, surface nanotopography, and substrate stiffness, on FAK expression and phosphorylation is summarized, seeking to identify which surface properties trigger initial cell signaling at the material interface.

ホスト出版物のタイトルPolymers in Regenerative Medicine
ホスト出版物のサブタイトルBiomedical Applications from Nano- to Macro-Structures
出版物ステータス出版済み - 1 30 2014

All Science Journal Classification (ASJC) codes

  • Engineering(all)
  • Chemical Engineering(all)
  • Materials Science(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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  • これを引用

    González-García, C., Salmerón-Sánchez, M., & García, A. J. (2014). Focal Adhesion Kinase in Cell-Material Interactions. : Polymers in Regenerative Medicine: Biomedical Applications from Nano- to Macro-Structures (pp. 147-176). wiley.