Focal segmental glomerulosclerosis in a patient with isolated ACTH deficiency and reversible hypothyroidism

Shunsuke Yamada, Sachiko Bandai, Kohsuke Masutani, Akihiro Tsuchimoto, Hideko Noguchi, Mikio Munakata, Kazuhiko Tsuruya, Mitsuo Iida

研究成果: Contribution to journalArticle

6 被引用数 (Scopus)

抄録

A 23-year-old man was admitted to our hospital for fatigue, anorexia, proteinuria, and peripheral edema. Proteinuria was first pointed out at the age of 15, but no further studies were performed. Six years prior to admission, the patient noted becoming easily fatigued. Laboratory tests on admission showed marked peripheral eosinophilia (29.2%, count: 1,071/μL) and proteinuria. Endocrinological studies revealed isolated adrenocorticotropic hormone deficiency with primary hypothyroidism, but a lack of autoimmune thyroiditis. Renal biopsy showed focal segmental glomerulosclerosis. Hydrocortisone therapy (30 mg/day) for isolated adrenocorticotropic hormone deficiency resulted in marked improvement of adrenal and thyroid functions, and amelioration of proteinuria (from 2.8 to 1.0 g/day) over a two-month period. Renal function remains normal at five years after the start of hydrocortisone treatment. The findings suggest that both hydrocortisone therapy and normalized thyroid hormone status played a pivotal role in the improvement of proteinuria associated with focal segmental glomerulosclerosis.

本文言語英語
ページ(範囲)168-172
ページ数5
ジャーナルClinical and Experimental Nephrology
14
2
DOI
出版ステータス出版済み - 4 2010

All Science Journal Classification (ASJC) codes

  • Physiology
  • Nephrology
  • Physiology (medical)

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