Folding dynamics of tethered giant DNA under strong flow

Takuya Saito, Takahiro Sakaue, Daiji Kaneko, Masao Washizu, Hidehiro Oana

研究成果: ジャーナルへの寄稿学術誌査読

4 被引用数 (Scopus)

抄録

Using a microfluidic device, we investigate the folding dynamics of individual linear long DNA, whose one end is tethered under a strong flow in the presence of a condensing agent. Direct observations of the folding process of DNA molecules reveal a characteristic dynamics with pronounced non-monotonic velocity of the folded part at the free end against the flow. We discuss this unique dynamics in relation to the inhomogeneous spatial fluctuation and the structure change at the multiple order levels along the stretched DNA, which is induced by the increasing tension due to the build-up of the hydrodynamic drag force.

本文言語英語
論文番号154901
ジャーナルJournal of Chemical Physics
135
15
DOI
出版ステータス出版済み - 10月 21 2011

!!!All Science Journal Classification (ASJC) codes

  • 物理学および天文学(全般)
  • 物理化学および理論化学

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