Follow-up study after resection of intraductal papillary mucinous neoplasm of the pancreas; special references to the multifocal lesions and development of ductal carcinoma in the remnant pancreas

Ohtsuka Takao, Hiroshi Kono, Reiko Tanabe, Yosuke Nagayoshi, Yasuhisa Mori, Yoshihiko Sadakari, Shunichi Takahata, Yasunori Oda, Shinichi Aishima, Hisato Igarashi, Tetsuhide Ito, Kosei Ishigami, Masafumi Nakamura, Kazuhiro Mizumoto, Masao Tanaka

研究成果: ジャーナルへの寄稿記事

71 引用 (Scopus)

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BACKGROUND: Frequency and characteristics of metachronous occurrence of multifocal intraductal papillary mucinous neoplasms (IPMNs) or distinct pancreatic ductal adenocarcinomas (PDACs) in the remnant pancreas during follow-up evaluation after pancreatectomy for IPMNs have not been well known. The aim of this study was to investigate the outcomes after resection of IPMNs, especially focusing on the metachronous occurrence of multifocal IPMNs and distinct PDACs. METHODS: Medical records of 172 patients who underwent resection of IPMNs were reviewed retrospectively, and the data regarding the occurrence of metachronous IPMNs or PDACs in the remnant pancreas during a mean postoperative follow-up period of 64 months were collected. RESULTS: The incidence including synchronous and metachronous multifocal occurrence of IPMNs was 20% (34 of 172), and that of distinct PDACs was 9.9% (17 of 172). Ten metachronous IPMNs developed in the remnant pancreas after a mean time of 23 postoperative months (range, 12-84 mo), and 2 with main duct IPMNs (both were carcinoma in situ) required remnant pancreatectomy. Six distinct PDACs developed in the remnant pancreas after a mean time of 84 postoperative months (range, 12-150 mo). Four of them were found to have a tumor with a size of less than 2 cm, whereas the remaining 2 PDACs were found to be unresectable more than 10 years after resection of IPMNs. CONCLUSIONS: Intense long-term follow-up evaluation is necessary for the early detection of metachronous occurrence of distinct PDACs as well as malignant IPMNs after resection of IPMNs.

元の言語英語
ページ(範囲)44-48
ページ数5
ジャーナルAmerican Journal of Surgery
204
発行部数1
DOI
出版物ステータス出版済み - 7 1 2012

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Ductal Carcinoma
Pancreatic Neoplasms
Pancreas
Adenocarcinoma
Neoplasms
Pancreatectomy
Carcinoma in Situ
Medical Records

All Science Journal Classification (ASJC) codes

  • Surgery

これを引用

Follow-up study after resection of intraductal papillary mucinous neoplasm of the pancreas; special references to the multifocal lesions and development of ductal carcinoma in the remnant pancreas. / Takao, Ohtsuka; Kono, Hiroshi; Tanabe, Reiko; Nagayoshi, Yosuke; Mori, Yasuhisa; Sadakari, Yoshihiko; Takahata, Shunichi; Oda, Yasunori; Aishima, Shinichi; Igarashi, Hisato; Ito, Tetsuhide; Ishigami, Kosei; Nakamura, Masafumi; Mizumoto, Kazuhiro; Tanaka, Masao.

:: American Journal of Surgery, 巻 204, 番号 1, 01.07.2012, p. 44-48.

研究成果: ジャーナルへの寄稿記事

Takao, Ohtsuka ; Kono, Hiroshi ; Tanabe, Reiko ; Nagayoshi, Yosuke ; Mori, Yasuhisa ; Sadakari, Yoshihiko ; Takahata, Shunichi ; Oda, Yasunori ; Aishima, Shinichi ; Igarashi, Hisato ; Ito, Tetsuhide ; Ishigami, Kosei ; Nakamura, Masafumi ; Mizumoto, Kazuhiro ; Tanaka, Masao. / Follow-up study after resection of intraductal papillary mucinous neoplasm of the pancreas; special references to the multifocal lesions and development of ductal carcinoma in the remnant pancreas. :: American Journal of Surgery. 2012 ; 巻 204, 番号 1. pp. 44-48.
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title = "Follow-up study after resection of intraductal papillary mucinous neoplasm of the pancreas; special references to the multifocal lesions and development of ductal carcinoma in the remnant pancreas",
abstract = "BACKGROUND: Frequency and characteristics of metachronous occurrence of multifocal intraductal papillary mucinous neoplasms (IPMNs) or distinct pancreatic ductal adenocarcinomas (PDACs) in the remnant pancreas during follow-up evaluation after pancreatectomy for IPMNs have not been well known. The aim of this study was to investigate the outcomes after resection of IPMNs, especially focusing on the metachronous occurrence of multifocal IPMNs and distinct PDACs. METHODS: Medical records of 172 patients who underwent resection of IPMNs were reviewed retrospectively, and the data regarding the occurrence of metachronous IPMNs or PDACs in the remnant pancreas during a mean postoperative follow-up period of 64 months were collected. RESULTS: The incidence including synchronous and metachronous multifocal occurrence of IPMNs was 20{\%} (34 of 172), and that of distinct PDACs was 9.9{\%} (17 of 172). Ten metachronous IPMNs developed in the remnant pancreas after a mean time of 23 postoperative months (range, 12-84 mo), and 2 with main duct IPMNs (both were carcinoma in situ) required remnant pancreatectomy. Six distinct PDACs developed in the remnant pancreas after a mean time of 84 postoperative months (range, 12-150 mo). Four of them were found to have a tumor with a size of less than 2 cm, whereas the remaining 2 PDACs were found to be unresectable more than 10 years after resection of IPMNs. CONCLUSIONS: Intense long-term follow-up evaluation is necessary for the early detection of metachronous occurrence of distinct PDACs as well as malignant IPMNs after resection of IPMNs.",
author = "Ohtsuka Takao and Hiroshi Kono and Reiko Tanabe and Yosuke Nagayoshi and Yasuhisa Mori and Yoshihiko Sadakari and Shunichi Takahata and Yasunori Oda and Shinichi Aishima and Hisato Igarashi and Tetsuhide Ito and Kosei Ishigami and Masafumi Nakamura and Kazuhiro Mizumoto and Masao Tanaka",
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T1 - Follow-up study after resection of intraductal papillary mucinous neoplasm of the pancreas; special references to the multifocal lesions and development of ductal carcinoma in the remnant pancreas

AU - Takao, Ohtsuka

AU - Kono, Hiroshi

AU - Tanabe, Reiko

AU - Nagayoshi, Yosuke

AU - Mori, Yasuhisa

AU - Sadakari, Yoshihiko

AU - Takahata, Shunichi

AU - Oda, Yasunori

AU - Aishima, Shinichi

AU - Igarashi, Hisato

AU - Ito, Tetsuhide

AU - Ishigami, Kosei

AU - Nakamura, Masafumi

AU - Mizumoto, Kazuhiro

AU - Tanaka, Masao

PY - 2012/7/1

Y1 - 2012/7/1

N2 - BACKGROUND: Frequency and characteristics of metachronous occurrence of multifocal intraductal papillary mucinous neoplasms (IPMNs) or distinct pancreatic ductal adenocarcinomas (PDACs) in the remnant pancreas during follow-up evaluation after pancreatectomy for IPMNs have not been well known. The aim of this study was to investigate the outcomes after resection of IPMNs, especially focusing on the metachronous occurrence of multifocal IPMNs and distinct PDACs. METHODS: Medical records of 172 patients who underwent resection of IPMNs were reviewed retrospectively, and the data regarding the occurrence of metachronous IPMNs or PDACs in the remnant pancreas during a mean postoperative follow-up period of 64 months were collected. RESULTS: The incidence including synchronous and metachronous multifocal occurrence of IPMNs was 20% (34 of 172), and that of distinct PDACs was 9.9% (17 of 172). Ten metachronous IPMNs developed in the remnant pancreas after a mean time of 23 postoperative months (range, 12-84 mo), and 2 with main duct IPMNs (both were carcinoma in situ) required remnant pancreatectomy. Six distinct PDACs developed in the remnant pancreas after a mean time of 84 postoperative months (range, 12-150 mo). Four of them were found to have a tumor with a size of less than 2 cm, whereas the remaining 2 PDACs were found to be unresectable more than 10 years after resection of IPMNs. CONCLUSIONS: Intense long-term follow-up evaluation is necessary for the early detection of metachronous occurrence of distinct PDACs as well as malignant IPMNs after resection of IPMNs.

AB - BACKGROUND: Frequency and characteristics of metachronous occurrence of multifocal intraductal papillary mucinous neoplasms (IPMNs) or distinct pancreatic ductal adenocarcinomas (PDACs) in the remnant pancreas during follow-up evaluation after pancreatectomy for IPMNs have not been well known. The aim of this study was to investigate the outcomes after resection of IPMNs, especially focusing on the metachronous occurrence of multifocal IPMNs and distinct PDACs. METHODS: Medical records of 172 patients who underwent resection of IPMNs were reviewed retrospectively, and the data regarding the occurrence of metachronous IPMNs or PDACs in the remnant pancreas during a mean postoperative follow-up period of 64 months were collected. RESULTS: The incidence including synchronous and metachronous multifocal occurrence of IPMNs was 20% (34 of 172), and that of distinct PDACs was 9.9% (17 of 172). Ten metachronous IPMNs developed in the remnant pancreas after a mean time of 23 postoperative months (range, 12-84 mo), and 2 with main duct IPMNs (both were carcinoma in situ) required remnant pancreatectomy. Six distinct PDACs developed in the remnant pancreas after a mean time of 84 postoperative months (range, 12-150 mo). Four of them were found to have a tumor with a size of less than 2 cm, whereas the remaining 2 PDACs were found to be unresectable more than 10 years after resection of IPMNs. CONCLUSIONS: Intense long-term follow-up evaluation is necessary for the early detection of metachronous occurrence of distinct PDACs as well as malignant IPMNs after resection of IPMNs.

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