Food-drug interaction of tacrolimus with pomelo, ginger, and turmeric juice in rats

Kanoko Egashira, Hitoshi Sasaki, Shun Higuchi, Ichiro Ieiri

研究成果: ジャーナルへの寄稿記事

28 引用 (Scopus)

抄録

Tacrolimus is a well-known potent immunosuppressant agent, which has various drug-drug or food-drug interactions. Previously, we found a renal transplant recipient who increased tacrolimus blood concentrations after ingestion of pomelo as a rare case. So, we investigated the effect of pomelo after its administration for one day or 3 consecutive days on the pharmacokinetics of tacrolimus in rats. We also confirmed the effects of grapefruit, turmeric, and ginger. The tacrolimus blood concentrations of the rats pre-treated with 100% pomelo juice were significantly higher than those pre-treated with water. On the other hand, the tacrolimus blood concentrations of the rats pre-treated with 50% pomelo juice were not significantly different from those pre-treated with water. The pomelo-tacrolimus interaction showed concentration dependency. Even low concentration of pomelo juice could enhance the blood concentrations of tacrolimus by repeated administration. The inhibitory effect of 100% pomelo juice disappeared 3 days after intake. The AUC values of tacrolimus in the rats pre-treated with grapefruit juice, ginger juice, and turmeric juice were significantly larger than those pre-treated with water. We could confirm the pomelotacrolimus interaction, which we discovered in a case study, quantitatively. We newly found the influence of turmeric and ginger on tacrolimus pharmacokinetics, comparable to pomelo.

元の言語英語
ページ(範囲)242-247
ページ数6
ジャーナルDrug Metabolism and Pharmacokinetics
27
発行部数2
DOI
出版物ステータス出版済み - 1 1 2012

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Food-Drug Interactions
Ginger
Curcuma
Tacrolimus
Citrus paradisi
Water
Pharmacokinetics
Immunosuppressive Agents
Pharmaceutical Preparations
Area Under Curve
Eating
Kidney

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science
  • Pharmacology (medical)

これを引用

Food-drug interaction of tacrolimus with pomelo, ginger, and turmeric juice in rats. / Egashira, Kanoko; Sasaki, Hitoshi; Higuchi, Shun; Ieiri, Ichiro.

:: Drug Metabolism and Pharmacokinetics, 巻 27, 番号 2, 01.01.2012, p. 242-247.

研究成果: ジャーナルへの寄稿記事

Egashira, Kanoko ; Sasaki, Hitoshi ; Higuchi, Shun ; Ieiri, Ichiro. / Food-drug interaction of tacrolimus with pomelo, ginger, and turmeric juice in rats. :: Drug Metabolism and Pharmacokinetics. 2012 ; 巻 27, 番号 2. pp. 242-247.
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abstract = "Tacrolimus is a well-known potent immunosuppressant agent, which has various drug-drug or food-drug interactions. Previously, we found a renal transplant recipient who increased tacrolimus blood concentrations after ingestion of pomelo as a rare case. So, we investigated the effect of pomelo after its administration for one day or 3 consecutive days on the pharmacokinetics of tacrolimus in rats. We also confirmed the effects of grapefruit, turmeric, and ginger. The tacrolimus blood concentrations of the rats pre-treated with 100{\%} pomelo juice were significantly higher than those pre-treated with water. On the other hand, the tacrolimus blood concentrations of the rats pre-treated with 50{\%} pomelo juice were not significantly different from those pre-treated with water. The pomelo-tacrolimus interaction showed concentration dependency. Even low concentration of pomelo juice could enhance the blood concentrations of tacrolimus by repeated administration. The inhibitory effect of 100{\%} pomelo juice disappeared 3 days after intake. The AUC values of tacrolimus in the rats pre-treated with grapefruit juice, ginger juice, and turmeric juice were significantly larger than those pre-treated with water. We could confirm the pomelotacrolimus interaction, which we discovered in a case study, quantitatively. We newly found the influence of turmeric and ginger on tacrolimus pharmacokinetics, comparable to pomelo.",
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