TY - JOUR
T1 - Forced swimming and imipramine modify plasma and brain amino acid concentrations in mice
AU - Murakami, Tatsuro
AU - Yamane, Haruka
AU - Tomonaga, Shozo
AU - Furuse, Mitsuhiro
N1 - Funding Information:
This work was supported by a Grant-in-Aid for Scientific Research from Japan Society for the Promotion of Science and MEXT City Area Program (Development Stage). The authors are grateful to the staff and students of the Laboratory of Chemistry and Technology of Animal Products in Kyushu University for their assistance in the amino acid analysis.
PY - 2009/1/5
Y1 - 2009/1/5
N2 - The relationships between monoamine metabolism and forced swimming or antidepressants have been well studied, however information is lacking regarding amino acid metabolism under these conditions. Therefore, the aim of the present study was to investigate the effects of forced swimming and imipramine on amino acid concentrations in plasma, the cerebral cortex and the hypothalamus in mice. Forced swimming caused cerebral cortex concentrations of l-glutamine, l-alanine, and taurine to be increased, while imipramine treatment caused decreased concentrations of l-glutamate, l-alanine, l-tyrosine, l-methionine, and l-ornithine. In the hypothalamus, forced swimming decreased the concentration of l-serine while imipramine treatment caused increased concentration of β-alanine. Forced swimming caused increased plasma concentration of taurine, while concentrations of l-serine, l-asparagine, l-glutamine and β-alanine were decreased. Imipramine treatment caused increased plasma concentration of all amino acid, except for l-aspartate and taurine. In conclusion, forced swimming and imipramine treatment modify central and peripheral amino acid metabolism. These results may aid in the identification of amino acids that have antidepressant-like effects, or may help to refine the dosages of antidepressant drugs.
AB - The relationships between monoamine metabolism and forced swimming or antidepressants have been well studied, however information is lacking regarding amino acid metabolism under these conditions. Therefore, the aim of the present study was to investigate the effects of forced swimming and imipramine on amino acid concentrations in plasma, the cerebral cortex and the hypothalamus in mice. Forced swimming caused cerebral cortex concentrations of l-glutamine, l-alanine, and taurine to be increased, while imipramine treatment caused decreased concentrations of l-glutamate, l-alanine, l-tyrosine, l-methionine, and l-ornithine. In the hypothalamus, forced swimming decreased the concentration of l-serine while imipramine treatment caused increased concentration of β-alanine. Forced swimming caused increased plasma concentration of taurine, while concentrations of l-serine, l-asparagine, l-glutamine and β-alanine were decreased. Imipramine treatment caused increased plasma concentration of all amino acid, except for l-aspartate and taurine. In conclusion, forced swimming and imipramine treatment modify central and peripheral amino acid metabolism. These results may aid in the identification of amino acids that have antidepressant-like effects, or may help to refine the dosages of antidepressant drugs.
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U2 - 10.1016/j.ejphar.2008.10.049
DO - 10.1016/j.ejphar.2008.10.049
M3 - Article
C2 - 19010319
AN - SCOPUS:57249112232
VL - 602
SP - 73
EP - 77
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 1
ER -