Forkhead box class O family member proteins: The biology and pathophysiological roles in diabetes

Kyoichiro Tsuchiya, Yoshihiro Ogawa

研究成果: Contribution to journalReview article査読

24 被引用数 (Scopus)

抄録

Forkhead box class O family member proteins (FoxOs) of transcription factors are essential regulators of cellular homeostasis, including glucose and lipid metabolism, oxidative stress response and redox signaling, cell cycle progression, and apoptosis. Altered FoxO1 expression and activity have been associated with glucose intolerance, dyslipidemia and complications of diabetes. In the liver, they direct carbons to glucose or lipid utilization, thus providing a unifying mechanism for the two abnormalities of the diabetic liver: excessive glucose production, and increased lipid synthesis and secretion. In the pancreas, FoxO1 is necessary to maintain β-cell differentiation, and could be promising targets for β-cell regeneration. In endothelial cells, FoxOs strongly promote atherosclerosis through suppressing nitric oxide production and enhancing inflammatory responses. In the present review, we summarize the basic biology and pathophysiological significance of FoxOs in diabetes.

本文言語英語
ページ(範囲)726-734
ページ数9
ジャーナルJournal of Diabetes Investigation
8
6
DOI
出版ステータス出版済み - 11 2017
外部発表はい

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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