Formation of highly analgesic morphine-6-glucuronide following physiologic concentration of morphine in human brain

Hideyuki Yamada, Kumiko Ishii, Yuji Ishii, Ichiro Ieiri, Syunji Nishio, Takato Morioka, Kazuta Oguri

研究成果: Contribution to journalArticle

39 被引用数 (Scopus)

抄録

3H-Morphine at physiologic concentration was metabolized in vitro to its 3- and 6-glucuronides by human brain homogenate. Recombinant UGT2B7, one of the UDP-glucuronosyltransferase (UGT) isoforms, is able to glucuronidate the 3- and 6-hydroxy groups of morphine at nanomolar concentrations. These results suggest that endogenous morphine is converted to its 6-glucuronide, a more highly analgesic substance than the parent compound, to suppress effectively pain symptoms in humans.

本文言語英語
ページ(範囲)395-401
ページ数7
ジャーナルJournal of Toxicological Sciences
28
5
DOI
出版ステータス出版済み - 12 2003

All Science Journal Classification (ASJC) codes

  • Toxicology

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