抄録
3H-Morphine at physiologic concentration was metabolized in vitro to its 3- and 6-glucuronides by human brain homogenate. Recombinant UGT2B7, one of the UDP-glucuronosyltransferase (UGT) isoforms, is able to glucuronidate the 3- and 6-hydroxy groups of morphine at nanomolar concentrations. These results suggest that endogenous morphine is converted to its 6-glucuronide, a more highly analgesic substance than the parent compound, to suppress effectively pain symptoms in humans.
本文言語 | 英語 |
---|---|
ページ(範囲) | 395-401 |
ページ数 | 7 |
ジャーナル | Journal of Toxicological Sciences |
巻 | 28 |
号 | 5 |
DOI | |
出版ステータス | 出版済み - 12月 2003 |
!!!All Science Journal Classification (ASJC) codes
- 毒物学