Formylation Reaction of Amines Using N-Formylcarbazole

Bubwoong Kang, Yuki Shimizu, Yusaku Tamura, Eigo Fukuda, Ken Ichiro Hamamoto, Yuichiro Uchida, Yoko Yasuno, Atsushi Nakayama, Tetsuya Satoh, Masaki Kuse, Tetsuro Shinada

研究成果: ジャーナルへの寄稿学術誌査読

抄録

Formamides are useful starting materials for pharmaceutical syntheses. Although various synthetic methods have been documented in this regard, the use of N-formylcarbazole as a formylation reagent for amines has not yet been reported. We report here the first examples of the use of N-formylcarbazole for the formylation of amines. The characteristic reactivity of N-formylcarbazole enables the selective formylation of sterically less hindered aliphatic primary and secondary amines. In contrast, sterically bulkier amines and weakly nucleophilic amines such as anilines are less reactive under the reaction conditions.

本文言語英語
ページ(範囲)492-497
ページ数6
ジャーナルChemical & pharmaceutical bulletin
70
7
DOI
出版ステータス出版済み - 2022

!!!All Science Journal Classification (ASJC) codes

  • 化学 (全般)
  • 創薬

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