Forsskamide, a new ceramide from aerial parts of Forsskaolea tenacissima Linn.

Hamdy K. Assaf, Alaa M. Nafady, Ahmed E. Allam, Ashraf N.E. Hamed, Mohamed S. Kamel, Kuniyoshi Shimizu

研究成果: ジャーナルへの寄稿記事

抄録

Although the various folk medicine uses and the biological activity of Forsskaolea tenacissima L., few chemical constituents of this plant have been reported, this provoked us to make our study. Forsskamide, a new ceramide was isolated from aerial parts of F. tenacissima L. (Urticaceae). The chemical structure was established by different spectroscopic methods (1H, 13C-NMR, HMBC, HSQC, ROESY, FAB-MS and HR-FAB-MS). Forsskamide showed a moderate cytotoxic activity by (MTT) method against human colorectal carcinoma cell line (HCT-116) with IC50 33.25 μM in comparison with 5-fluorouracil IC50 26.42 μM. While, it did not show any activity against human hepatocarcinaoma cell line (HepG-2).

元の言語英語
ページ(範囲)2452-2456
ページ数5
ジャーナルNatural Product Research
32
発行部数20
DOI
出版物ステータス出版済み - 10 18 2018

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ceramides
Ceramides
Inhibitory Concentration 50
aerial parts
inhibitory concentration 50
Urticaceae
Cells
Antennas
chemical constituents of plants
fluorouracil
Cell Line
human cell lines
Traditional Medicine
traditional medicine
Bioactivity
colorectal neoplasms
Human Activities
Fluorouracil
chemical structure
Medicine

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

これを引用

Forsskamide, a new ceramide from aerial parts of Forsskaolea tenacissima Linn. / Assaf, Hamdy K.; Nafady, Alaa M.; Allam, Ahmed E.; Hamed, Ashraf N.E.; Kamel, Mohamed S.; Shimizu, Kuniyoshi.

:: Natural Product Research, 巻 32, 番号 20, 18.10.2018, p. 2452-2456.

研究成果: ジャーナルへの寄稿記事

Assaf, Hamdy K. ; Nafady, Alaa M. ; Allam, Ahmed E. ; Hamed, Ashraf N.E. ; Kamel, Mohamed S. ; Shimizu, Kuniyoshi. / Forsskamide, a new ceramide from aerial parts of Forsskaolea tenacissima Linn. :: Natural Product Research. 2018 ; 巻 32, 番号 20. pp. 2452-2456.
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AU - Hamed, Ashraf N.E.

AU - Kamel, Mohamed S.

AU - Shimizu, Kuniyoshi

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