Four new cembrane diterpenes isolated from an Okinawan soft coral Lobophytum crassum with inhibitory effects on nitric oxide production

Mpanzu Wanzola, Takaaki Furuta, Yasuhisa Kohno, Shunichi Fukumitsu, Shuhei Yasukochi, Kosuke Watari, Chiaki Tanaka, Ryuichi Higuchi, Tomofumi Miyamoto

研究成果: ジャーナルへの寄稿記事

26 引用 (Scopus)

抄録

Four new cembrane diterpenes (1-4) and fifteen known cembranoids (5-19) were isolated from an Okinawan soft coral Lobophytum crassum. The structures of these four new cembranoids were determined on the basis of spectroscopic evidence. In particular, the absolute stereochemistry of 1, 2, 5 and 6 were elucidated by the application of the modified Mosher's method and circular dichroism (CD) spectral data. The inhibitory effects of some isolates were evaluated on nitric oxide (NO) production against a murine macrophage-like cell line (Raw 264.7). Cembranoids consisting of α-methylene-γ-lactone, exhibited the significant effect on NO production.

元の言語英語
ページ(範囲)1203-1209
ページ数7
ジャーナルChemical and Pharmaceutical Bulletin
58
発行部数9
DOI
出版物ステータス出版済み - 9 1 2010

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Anthozoa
Diterpenes
Nitric Oxide
Stereochemistry
Macrophages
Circular Dichroism
Cells
Cell Line
methylene-lactone

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

これを引用

Four new cembrane diterpenes isolated from an Okinawan soft coral Lobophytum crassum with inhibitory effects on nitric oxide production. / Wanzola, Mpanzu; Furuta, Takaaki; Kohno, Yasuhisa; Fukumitsu, Shunichi; Yasukochi, Shuhei; Watari, Kosuke; Tanaka, Chiaki; Higuchi, Ryuichi; Miyamoto, Tomofumi.

:: Chemical and Pharmaceutical Bulletin, 巻 58, 番号 9, 01.09.2010, p. 1203-1209.

研究成果: ジャーナルへの寄稿記事

Wanzola, Mpanzu ; Furuta, Takaaki ; Kohno, Yasuhisa ; Fukumitsu, Shunichi ; Yasukochi, Shuhei ; Watari, Kosuke ; Tanaka, Chiaki ; Higuchi, Ryuichi ; Miyamoto, Tomofumi. / Four new cembrane diterpenes isolated from an Okinawan soft coral Lobophytum crassum with inhibitory effects on nitric oxide production. :: Chemical and Pharmaceutical Bulletin. 2010 ; 巻 58, 番号 9. pp. 1203-1209.
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AU - Fukumitsu, Shunichi

AU - Yasukochi, Shuhei

AU - Watari, Kosuke

AU - Tanaka, Chiaki

AU - Higuchi, Ryuichi

AU - Miyamoto, Tomofumi

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