FOXO3 is essential for CD44 expression in pancreatic cancer cells

M. Kumazoe, M. Takai, J. Bae, S. Hiroi, Y. Huang, K. Takamatsu, Y. Won, M. Yamashita, S. Hidaka, S. Yamashita, S. Yamada, M. Murata, S. Tsukamoto, H. Tachibana

研究成果: Contribution to journalArticle査読

22 被引用数 (Scopus)

抄録

Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal types of cancer and the 5-year survival rate is only 5%. Several studies have suggested that cancer stem cells (CSCs) are thought to be involved in recurrence and metastasis and so it is essential to establish an approach targeting CSCs. Here we have demonstrated that cyclic guanosine monophosphate (cGMP) suppressed CD44 expression and the properties of CSCs in PDAC. Microarray analysis suggested that cGMP inhibited Forkhead box O3 (FOXO3), which is known as a tumor suppressor. Surprisingly, our data demonstrated that FOXO3 is essential for CD44 expression and the properties of CSCs. Our data also indicated that patients with high FOXO3 activation signatures had poor prognoses. This evidence suggested that cGMP induction and FOXO3 inhibition could be ideal candidates for pancreatic CSC.

本文言語英語
ページ(範囲)2643-2654
ページ数12
ジャーナルOncogene
36
19
DOI
出版ステータス出版済み - 5 11 2017

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cancer Research

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