Foxp3-Dependent MicroRNA155 Confers Competitive Fitness to Regulatory T Cells by Targeting SOCS1 Protein

Li Fan Lu, To Ha Thai, Dinis Pedro Calado, Ashutosh Chaudhry, Masato Kubo, Kentaro Tanaka, Gabriel B. Loeb, Hana Lee, Akihiko Yoshimura, Klaus Rajewsky, Alexander Y. Rudensky

研究成果: ジャーナルへの寄稿記事

521 引用 (Scopus)

抄録

Foxp3+ regulatory T (Treg) cells limit pathogenic immune responses to self-antigens and foreign antigens. An essential role for microRNA (miRNA) in the maintenance and function of Treg cells, revealed by the Treg cell-specific Dicer ablation, raised a question as to a specific miRNA contribution. We found that Foxp3 controlled the elevated miR155 expression required for maintaining Treg cell proliferative activity and numbers under nonlymphopenic conditions. Moreover, miR155 deficiency in Treg cells resulted in increased suppressor of cytokine signaling 1 (SOCS1) expression accompanied by impaired activation of signal transducer and activator of transcription 5 (STAT5) transcription factor in response to limiting amounts of interleukin-2. Our studies suggest that Foxp3-dependent regulation of miR155 maintains competitive fitness of Treg cell subsets by targeting SOCS1, and they provide experimental support for a proposed role for miRNAs in ensuring the robustness of cellular phenotypes.

元の言語英語
ページ(範囲)80-91
ページ数12
ジャーナルImmunity
30
発行部数1
DOI
出版物ステータス出版済み - 1 16 2009

Fingerprint

Regulatory T-Lymphocytes
MicroRNAs
STAT5 Transcription Factor
Cytokines
Autoantigens
Suppressor of Cytokine Signaling 1 Protein
Interleukin-2
Transcription Factors
Maintenance
Phenotype
Antigens

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

これを引用

Foxp3-Dependent MicroRNA155 Confers Competitive Fitness to Regulatory T Cells by Targeting SOCS1 Protein. / Lu, Li Fan; Thai, To Ha; Calado, Dinis Pedro; Chaudhry, Ashutosh; Kubo, Masato; Tanaka, Kentaro; Loeb, Gabriel B.; Lee, Hana; Yoshimura, Akihiko; Rajewsky, Klaus; Rudensky, Alexander Y.

:: Immunity, 巻 30, 番号 1, 16.01.2009, p. 80-91.

研究成果: ジャーナルへの寄稿記事

Lu, LF, Thai, TH, Calado, DP, Chaudhry, A, Kubo, M, Tanaka, K, Loeb, GB, Lee, H, Yoshimura, A, Rajewsky, K & Rudensky, AY 2009, 'Foxp3-Dependent MicroRNA155 Confers Competitive Fitness to Regulatory T Cells by Targeting SOCS1 Protein', Immunity, 巻. 30, 番号 1, pp. 80-91. https://doi.org/10.1016/j.immuni.2008.11.010
Lu, Li Fan ; Thai, To Ha ; Calado, Dinis Pedro ; Chaudhry, Ashutosh ; Kubo, Masato ; Tanaka, Kentaro ; Loeb, Gabriel B. ; Lee, Hana ; Yoshimura, Akihiko ; Rajewsky, Klaus ; Rudensky, Alexander Y. / Foxp3-Dependent MicroRNA155 Confers Competitive Fitness to Regulatory T Cells by Targeting SOCS1 Protein. :: Immunity. 2009 ; 巻 30, 番号 1. pp. 80-91.
@article{0946032ad32f493da0b9f62e0cdb3a67,
title = "Foxp3-Dependent MicroRNA155 Confers Competitive Fitness to Regulatory T Cells by Targeting SOCS1 Protein",
abstract = "Foxp3+ regulatory T (Treg) cells limit pathogenic immune responses to self-antigens and foreign antigens. An essential role for microRNA (miRNA) in the maintenance and function of Treg cells, revealed by the Treg cell-specific Dicer ablation, raised a question as to a specific miRNA contribution. We found that Foxp3 controlled the elevated miR155 expression required for maintaining Treg cell proliferative activity and numbers under nonlymphopenic conditions. Moreover, miR155 deficiency in Treg cells resulted in increased suppressor of cytokine signaling 1 (SOCS1) expression accompanied by impaired activation of signal transducer and activator of transcription 5 (STAT5) transcription factor in response to limiting amounts of interleukin-2. Our studies suggest that Foxp3-dependent regulation of miR155 maintains competitive fitness of Treg cell subsets by targeting SOCS1, and they provide experimental support for a proposed role for miRNAs in ensuring the robustness of cellular phenotypes.",
author = "Lu, {Li Fan} and Thai, {To Ha} and Calado, {Dinis Pedro} and Ashutosh Chaudhry and Masato Kubo and Kentaro Tanaka and Loeb, {Gabriel B.} and Hana Lee and Akihiko Yoshimura and Klaus Rajewsky and Rudensky, {Alexander Y.}",
year = "2009",
month = "1",
day = "16",
doi = "10.1016/j.immuni.2008.11.010",
language = "English",
volume = "30",
pages = "80--91",
journal = "Immunity",
issn = "1074-7613",
publisher = "Cell Press",
number = "1",

}

TY - JOUR

T1 - Foxp3-Dependent MicroRNA155 Confers Competitive Fitness to Regulatory T Cells by Targeting SOCS1 Protein

AU - Lu, Li Fan

AU - Thai, To Ha

AU - Calado, Dinis Pedro

AU - Chaudhry, Ashutosh

AU - Kubo, Masato

AU - Tanaka, Kentaro

AU - Loeb, Gabriel B.

AU - Lee, Hana

AU - Yoshimura, Akihiko

AU - Rajewsky, Klaus

AU - Rudensky, Alexander Y.

PY - 2009/1/16

Y1 - 2009/1/16

N2 - Foxp3+ regulatory T (Treg) cells limit pathogenic immune responses to self-antigens and foreign antigens. An essential role for microRNA (miRNA) in the maintenance and function of Treg cells, revealed by the Treg cell-specific Dicer ablation, raised a question as to a specific miRNA contribution. We found that Foxp3 controlled the elevated miR155 expression required for maintaining Treg cell proliferative activity and numbers under nonlymphopenic conditions. Moreover, miR155 deficiency in Treg cells resulted in increased suppressor of cytokine signaling 1 (SOCS1) expression accompanied by impaired activation of signal transducer and activator of transcription 5 (STAT5) transcription factor in response to limiting amounts of interleukin-2. Our studies suggest that Foxp3-dependent regulation of miR155 maintains competitive fitness of Treg cell subsets by targeting SOCS1, and they provide experimental support for a proposed role for miRNAs in ensuring the robustness of cellular phenotypes.

AB - Foxp3+ regulatory T (Treg) cells limit pathogenic immune responses to self-antigens and foreign antigens. An essential role for microRNA (miRNA) in the maintenance and function of Treg cells, revealed by the Treg cell-specific Dicer ablation, raised a question as to a specific miRNA contribution. We found that Foxp3 controlled the elevated miR155 expression required for maintaining Treg cell proliferative activity and numbers under nonlymphopenic conditions. Moreover, miR155 deficiency in Treg cells resulted in increased suppressor of cytokine signaling 1 (SOCS1) expression accompanied by impaired activation of signal transducer and activator of transcription 5 (STAT5) transcription factor in response to limiting amounts of interleukin-2. Our studies suggest that Foxp3-dependent regulation of miR155 maintains competitive fitness of Treg cell subsets by targeting SOCS1, and they provide experimental support for a proposed role for miRNAs in ensuring the robustness of cellular phenotypes.

UR - http://www.scopus.com/inward/record.url?scp=58149268107&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58149268107&partnerID=8YFLogxK

U2 - 10.1016/j.immuni.2008.11.010

DO - 10.1016/j.immuni.2008.11.010

M3 - Article

VL - 30

SP - 80

EP - 91

JO - Immunity

JF - Immunity

SN - 1074-7613

IS - 1

ER -