Free radical imaging of endogenous redox molecules using dynamic nuclear polarisation magnetic resonance imaging

Fuminori Hyodo, Shinji Ito, Hinako Eto, Abdelazim Elsayed Elhelaly, Masaharu Murata, Tomohiko Akahoshi, Hideo Utsumi, Masayuki Matuso

研究成果: Contribution to journalReview article査読

抄録

Redox reactions accompanied by the oxidation–reduction of endogenous molecules play important roles in maintaining homeostasis in living organisms. In humans, numerous endogenous molecules that contribute towards maintaining physiological conditions form free radicals via electron transfer. A typical example of this is the mitochondrial electron transport chain, which is involved in energy production. If free radicals derived from endogenous molecules could be visualised and exploited as biological and functional probes, redox reactions mediated by endogenous molecules could be detected non-invasively. We succeeded in visualising the free radicals derived from endogenous molecules using an in vivo dynamic nuclear polarisation (DNP) magnetic resonance imaging (MRI) system. In this review, we describe the visualisation of endogenous redox molecules, such as flavins and ubiquinones, which are mitochondrial electron carriers, as well as vitamin E and vitamin C (ascorbate). In addition, we describe the application of melanin free radicals for the in vivo visualisation of metabola without using probes via in vivo DNP-MRI.

本文言語英語
ジャーナルFree Radical Research
DOI
出版ステータス受理済み/印刷中 - 2020

All Science Journal Classification (ASJC) codes

  • 生化学

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