From stem cells to lymphocytes: Biology and transplantation

Hector L. Aguila, Koichi Akashi, Jos Domen, Kimberly L. Gandy, Eric Lagasse, Reina E. Mebius, Sean J. Morrison, Judy Shizuru, Samuel Strober, Nobuko Uchida, Douglas E. Wright, Irving L. Weissman

研究成果: Contribution to journalReview article査読

61 被引用数 (Scopus)

抄録

We review the development of the hematopoietic system, focusing on the transition from hematopoietic stem cells (HSCs) to T cells. This includes the isolation of HSCs, and recent progress in understanding their ontogeny, homing properties, and differentiation HSC transplantation is reviewed, including the kinetics of reconstitution, engraftment across histocompatibility barriers, the facilitation of allogeneic engraftment, and the mechanisms of graft rejection. We describe progress in understanding T-cell development in the bone marrow and thymus as well as the establishment of lymph nodes. Finally, the role of bcl-2 in regulating homeostasis in the hematopoietic system is discussed.

本文言語英語
ページ(範囲)13-39
ページ数27
ジャーナルImmunological Reviews
157
DOI
出版ステータス出版済み - 8 2 1997
外部発表はい

All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 免疫学

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