Full thickness macular hole case after intravitreal aflibercept treatment

Yuji Oshima, Rajendra S. Apte, Shintaro Nakao, Shigeo Yoshida, Tatsuro Ishibashi

研究成果: ジャーナルへの寄稿記事

12 引用 (Scopus)

抄録

Background: The pathogenesis of macular hole formation is widely accepted as a tractional force at the vitreo-retinal interface in fovea. We report a case of macular hole after intravitreous aflibercept injection for age-related macular degeneration (AMD) associated with contraction of the retinal pigment epithelium (RPE) at the edge of a fibrovascular pigment epithelial detachment (PED). Case presentation: A 94-year old man with neovascular AMD affecting his left eye accompanied by a fibrovascular PED was examined for severe vision loss. Although RPE tear in his left eye was identified before the first aflibercept intravitreous injection performed in order to treat neovascular AMD, he received three aflibercept injections as induction treatment. After induction treatment, a full thickness macular hole was identified associated with the contracted rolled RPE edge beneath the retina. Conclusion: Macular hole is commonly formed associated with tangential vitreous traction. Current report suggests that rapid contraction of the RPE underneath the retina can be one of the causes of a macular hole, and one of the side effects of anti-VEGF therapy for neovascular AMD.

元の言語英語
記事番号30
ジャーナルBMC Ophthalmology
15
発行部数1
DOI
出版物ステータス出版済み - 1 1 2015

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Retinal Perforations
Retinal Pigment Epithelium
Macular Degeneration
Injections
Retina
Therapeutics
Traction
Vascular Endothelial Growth Factor A
aflibercept

All Science Journal Classification (ASJC) codes

  • Ophthalmology

これを引用

Full thickness macular hole case after intravitreal aflibercept treatment. / Oshima, Yuji; Apte, Rajendra S.; Nakao, Shintaro; Yoshida, Shigeo; Ishibashi, Tatsuro.

:: BMC Ophthalmology, 巻 15, 番号 1, 30, 01.01.2015.

研究成果: ジャーナルへの寄稿記事

Oshima, Yuji ; Apte, Rajendra S. ; Nakao, Shintaro ; Yoshida, Shigeo ; Ishibashi, Tatsuro. / Full thickness macular hole case after intravitreal aflibercept treatment. :: BMC Ophthalmology. 2015 ; 巻 15, 番号 1.
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