[Function and role of transient receptor potential channels].

Motohiro Nishida, Masaaki Sumita, Naoyuki Kitajima

研究成果: ジャーナルへの寄稿評論記事

1 引用 (Scopus)

抄録

Transient receptor potential (TRP) proteins are components of Ca(2 +) -permeable non-selective cation channels activated by physical and chemical stimulus except for membrane depolarization. The pathophysiological role of TRP channels is documented in heart failure. Especially, canonical TRP subfamily C (TRPC) channels activated by neurohumoral factors have been implicated in the structural remodeling of the heart. TRPC proteins act not only as components of receptor-activated cation channels, but also as protein scaffold to form protein complex with intracellular signaling proteins, leading to amplification of receptor signaling. Recently, selective inhibitors of TRPC channels have been continuously identified, anticipating the possibility of drug discovery targeting TRPC channels for the treatment of heart failure.

元の言語英語
ページ(範囲)561-568
ページ数8
ジャーナルClinical calcium
23
発行部数4
出版物ステータス出版済み - 1 1 2013

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Transient Receptor Potential Channels
Cations
Intracellular Signaling Peptides and Proteins
Heart Failure
Proteins
Drug Discovery
Drug Delivery Systems
Protein C
Treatment Failure
Membranes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

これを引用

[Function and role of transient receptor potential channels]. / Nishida, Motohiro; Sumita, Masaaki; Kitajima, Naoyuki.

:: Clinical calcium, 巻 23, 番号 4, 01.01.2013, p. 561-568.

研究成果: ジャーナルへの寄稿評論記事

Nishida, M, Sumita, M & Kitajima, N 2013, '[Function and role of transient receptor potential channels].', Clinical calcium, 巻. 23, 番号 4, pp. 561-568.
Nishida, Motohiro ; Sumita, Masaaki ; Kitajima, Naoyuki. / [Function and role of transient receptor potential channels]. :: Clinical calcium. 2013 ; 巻 23, 番号 4. pp. 561-568.
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