TY - JOUR
T1 - Functional distinctions associated with the diversity of sex steroid hormone receptors ESR and AR
AU - Ogino, Yukiko
AU - Tohyama, Saki
AU - Kohno, Satomi
AU - Toyota, Kenji
AU - Yamada, Gen
AU - Yatsu, Ryohei
AU - Kobayashi, Tohru
AU - Tatarazako, Norihisa
AU - Sato, Tomomi
AU - Matsubara, Hajime
AU - Lange, Anke
AU - Tyler, Charles R.
AU - Katsu, Yoshinao
AU - Iguchi, Taisen
AU - Miyagawa, Shinichi
N1 - Funding Information:
This study was supported by Grants-in-Aid for Scientific Research (KAKENHI) [15K07138 (Y.O.), 15H04395 (Y.O.), 15H04396 (T.I., Y.O., S.M.), 26440173 (S.M.), 17H06432 (S.M.), 18H02474 (S.M.)] from the Japan Society for the Promotion of Science (JSPS): UK-Japan Research Collaboration Grants (T.K., N.T., A.L., C.R.T., S.M., T.I.) and grants (N.T., T.I., S.M.) from the Ministry of the Environment, Japan , and the Department for Environment, Food and Rural Affairs (Defra), UK: the NIBB Cooperative Research Program (Y.O., S.M.) from National Institute for Basic Biology : The 2nd Women Researchers Promotion Program, Support for childbirth and childcare in Women Researchers Promotion Program and Support for Women Returning from Maternity and Parental Leave from Kyushu University (Y.O.).
Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/11
Y1 - 2018/11
N2 - Sex steroid hormones including estrogens and androgens play fundamental roles in regulating reproductive activities and they act through estrogen and androgen receptors (ESR and AR). These steroid receptors have evolved from a common ancestor in association with several gene duplications. In most vertebrates, this has resulted in two ESR subtypes (ESR1 and ESR2) and one AR, whereas in teleost fish there are at least three ESRs (ESR1, ESR2a and ESR2b) and two ARs (ARα and ARβ) due to a lineage-specific whole genome duplication. Functional distinctions have been suggested among these receptors, but to date their roles have only been characterized in a limited number of species. Sexual differentiation and the development of reproductive organs are indispensable for all animal species and in vertebrates these events depend on the action of sex steroid hormones. Here we review the recent progress in understanding of the functions of the ESRs and ARs in the development and expression of sexually dimorphic characteristics associated with steroid hormone signaling in vertebrates, with representative fish, amphibians, reptiles, birds and mammals.
AB - Sex steroid hormones including estrogens and androgens play fundamental roles in regulating reproductive activities and they act through estrogen and androgen receptors (ESR and AR). These steroid receptors have evolved from a common ancestor in association with several gene duplications. In most vertebrates, this has resulted in two ESR subtypes (ESR1 and ESR2) and one AR, whereas in teleost fish there are at least three ESRs (ESR1, ESR2a and ESR2b) and two ARs (ARα and ARβ) due to a lineage-specific whole genome duplication. Functional distinctions have been suggested among these receptors, but to date their roles have only been characterized in a limited number of species. Sexual differentiation and the development of reproductive organs are indispensable for all animal species and in vertebrates these events depend on the action of sex steroid hormones. Here we review the recent progress in understanding of the functions of the ESRs and ARs in the development and expression of sexually dimorphic characteristics associated with steroid hormone signaling in vertebrates, with representative fish, amphibians, reptiles, birds and mammals.
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U2 - 10.1016/j.jsbmb.2018.06.002
DO - 10.1016/j.jsbmb.2018.06.002
M3 - Review article
C2 - 29885351
AN - SCOPUS:85048278779
VL - 184
SP - 38
EP - 46
JO - Journal of Steroid Biochemistry
JF - Journal of Steroid Biochemistry
SN - 0960-0760
ER -
