Functional Golgi units in microtubule-disrupted cultured atrial myocytes

Hiroshi Iida, Y. Shibata

研究成果: ジャーナルへの寄稿記事

20 引用 (Scopus)

抄録

We examined the effects of disassembly of microtubules (MT) on the structure and the functions of the Golgi apparatus (GA) in cultured atrial myocytes. MT disassembly with nocodazole led to fragmentation of the GA into small units. The fragmented Golgi units retained their cis-trans polarity and post-cisternal elements, including the trans-Golgi network (TGN). Neither endocytosis of lectin-labeled membrane nor its delivery to the fragmented Golgi units was interrupted by fragmentation of the GA after MT disassembly with nocodazole treatment. A fraction of the secretory granules associated with the fragmented Golgi units was also labeled with the internalized tracer. These results suggest that in nocodazole-treated cultured atrial myocytes, the fragmented Golgi units appear to be structurally and functionally intact despite the altered geometric arrangement of the GA in the cells.

元の言語英語
ページ(範囲)1349-1355
ページ数7
ジャーナルJournal of Histochemistry and Cytochemistry
39
発行部数10
DOI
出版物ステータス出版済み - 1 1 1991

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Golgi Apparatus
Nocodazole
Microtubules
Muscle Cells
trans-Golgi Network
Secretory Vesicles
Endocytosis
Lectins
Membranes

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Histology

これを引用

Functional Golgi units in microtubule-disrupted cultured atrial myocytes. / Iida, Hiroshi; Shibata, Y.

:: Journal of Histochemistry and Cytochemistry, 巻 39, 番号 10, 01.01.1991, p. 1349-1355.

研究成果: ジャーナルへの寄稿記事

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