Functional properties of neurotransmitter receptors transplanted into Xenopus oocytes

H. Sugiyama, C. Hirono, I. Ito, S. Yamagishi

研究成果: ジャーナルへの寄稿記事

抄録

When oocytes of African frog Xenopus laevis were injected with mRNA isolated from rat brains, the oocyted synthesized functional properties such as ionic channels or neurotransmitter receptors based on the injected mRNA. Functional properties of neurotransmitter receptors thus transplanted from rat brains were studied in the oocytes. Analyses of intracellular reaction mechanisms of these receptors revealed that, in this system, receptors that activate G-proteins and stimulate inositol phospholipid metabolism and intracellular Ca2+ mobilization were expressed very efficiently. Muscarinic acetylcholine receptor is a typical one of this category. Neurotensin receptor was also found to belong to this category. In addition, a new subtype pf glutamate receptor was found that stimulates the same intracellular reactions. This is the first direct evidence for a glutamate receptor subtype that stimulates G-protein-mediated reactions.

元の言語英語
ページ(範囲)55-58
ページ数4
ジャーナルBiomedical Research
8
発行部数SUPPL. 1987
出版物ステータス出版済み - 1 1 1987

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Neurotransmitter Receptor
Glutamate Receptors
Xenopus
GTP-Binding Proteins
Oocytes
Rats
Brain
Neurotensin Receptors
Messenger RNA
Xenopus laevis
Muscarinic Receptors
Phosphatidylinositols
Ion Channels
Metabolism
Anura

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

これを引用

Sugiyama, H., Hirono, C., Ito, I., & Yamagishi, S. (1987). Functional properties of neurotransmitter receptors transplanted into Xenopus oocytes. Biomedical Research, 8(SUPPL. 1987), 55-58.

Functional properties of neurotransmitter receptors transplanted into Xenopus oocytes. / Sugiyama, H.; Hirono, C.; Ito, I.; Yamagishi, S.

:: Biomedical Research, 巻 8, 番号 SUPPL. 1987, 01.01.1987, p. 55-58.

研究成果: ジャーナルへの寄稿記事

Sugiyama, H, Hirono, C, Ito, I & Yamagishi, S 1987, 'Functional properties of neurotransmitter receptors transplanted into Xenopus oocytes', Biomedical Research, 巻. 8, 番号 SUPPL. 1987, pp. 55-58.
Sugiyama H, Hirono C, Ito I, Yamagishi S. Functional properties of neurotransmitter receptors transplanted into Xenopus oocytes. Biomedical Research. 1987 1 1;8(SUPPL. 1987):55-58.
Sugiyama, H. ; Hirono, C. ; Ito, I. ; Yamagishi, S. / Functional properties of neurotransmitter receptors transplanted into Xenopus oocytes. :: Biomedical Research. 1987 ; 巻 8, 番号 SUPPL. 1987. pp. 55-58.
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