Functionalization of crown ethers: An approach to the enzyme model for peptide synthesis

Kenji Koga, Shigeki Sasaki

研究成果: Contribution to journalArticle査読

18 被引用数 (Scopus)

抄録

Chiral crown ethers having two thiol groups were designed and synthesized as an approach to the enzyme model for peptide synthesis. The strategy of the present method consists of four fundamental steps as shown in Scheme II, i.e., (1) mono-ester formation by intracomplex thiolysis followed by protection of the amino group (6 to 10), (2) di-ester formation by intracomplex thiolysis (10 to 13), (3) peptide bond formation by intramolecular aminolysis with regeneration of one free thiol group (13 to 15), and (4) elongation of peptide chain by repeating the above steps (2) and (3). Synthesis of tri- and tetra-peptide derivatives by this method is descirbed.

本文言語英語
ページ(範囲)539-543
ページ数5
ジャーナルPure and Applied Chemistry
60
4
DOI
出版ステータス出版済み - 1 1 1988

All Science Journal Classification (ASJC) codes

  • 化学 (全般)
  • 化学工学(全般)

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