Fusiform gyrus volume reduction in first-episode schizophrenia: A magnetic resonance imaging study

Chang Uk Lee, Martha E. Shenton, Dean F. Salisbury, Kiyoto Kasai, Toshiaki Onitsuka, Chandlee C. Dickey, Deborah Yurgelun-Todd, Ron Kikinis, Ferenc A. Jolesz, Robert W. McCarley

研究成果: Contribution to journalArticle査読

113 被引用数 (Scopus)

抄録

Background: The fusiform gyrus (occipitotemporal gyrus) is thought to be critical for face recognition and may possibly be associated with impaired facial recognition and interpretation of facial expression in schizophrenia. Results of postmortem studies have suggested that fusiform gyrus volume is reduced in schizophrenia, but there have been no in vivo structural studies of the fusiform gyrus in schizophrenia using magnetic resonance imaging. Methods: High-spatial resolution magnetic resonance images were used to measure the gray matter volume of the fusiform gyrus in 22 patients with first-episode schizophrenia (first hospitalization), 20 with first-episode affective psychosis (mainly manic), and 24 control subjects. Results: Patients with first-episode schizophrenia had overall smaller relative volumes (absolute volume/intracranial contents) of fusiform gyrus gray matter compared with controls (9%) and patients with affective psychosis (7%). For the left fusiform gyrus, patients with schizophrenia showed an 11% reduction compared with controls and patients with affective psychosis. Right fusiform gyrus volume differed in patients with schizophrenia only compared with controls (8%). Conclusion: Schizophrenia is associated with a bilateral reduction in fusiform gyrus gray matter volume that is evident at the time of first hospitalization and is different from the presentation of affective psychosis.

本文言語英語
ページ(範囲)775-781
ページ数7
ジャーナルArchives of General Psychiatry
59
9
DOI
出版ステータス出版済み - 9 2002
外部発表はい

All Science Journal Classification (ASJC) codes

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

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