G-protein gamma subunit 1 is required for sugar reception in Drosophila

Hiroshi Ishimoto, Kuniaki Takahashi, Ryu Ueda, Teiichi Tanimura

研究成果: Contribution to journalArticle

41 引用 (Scopus)

抜粋

Though G-proteins have been implicated in the primary step of taste signal transduction, no direct demonstration has been done in insects. We show here that a G-protein gamma subunit, Gγ1, is required for the signal transduction of sugar taste reception in Drosophila. The Gγ1 gene is expressed mainly in one of the gustatory receptor neurons. Behavioral responses of the flies to sucrose were reduced by the targeted suppression of neural functions of Gγ1-expressing cells using neural modulator genes such as the modified Shaker K+ channel (EKO), the tetanus toxin light chain or the shibire (shits1) gene. RNA interference targeting to the Gγ1 gene reduced the amount of Gγ1 mRNA and suppressed electrophysiological response of the sugar receptor neuron. We also demonstrated that responses to sugars were lowered in Gγ1 null mutant, Gγ1 N159. These results are consistent with the hypothesis that Gγ1 participates in the signal transduction of sugar taste reception.

元の言語英語
ページ(範囲)3259-3265
ページ数7
ジャーナルEMBO Journal
24
発行部数18
DOI
出版物ステータス出版済み - 9 21 2005

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

フィンガープリント G-protein gamma subunit 1 is required for sugar reception in Drosophila' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Ishimoto, H., Takahashi, K., Ueda, R., & Tanimura, T. (2005). G-protein gamma subunit 1 is required for sugar reception in Drosophila. EMBO Journal, 24(18), 3259-3265. https://doi.org/10.1038/sj.emboj.7600796