Gadoxetate disodium-related event during image acquisition: a prospective multi-institutional study for better MR practice

Marie Luise Kromrey, Masatoshi Hori, Satoshi Goshima, Kazuto Kozaka, Tomoko Hyodo, Yuko Nakamura, Akihiro Nishie, Tsutomu Tamada, Tatsuya Shimizu, Akihiko Kanki, Utaroh Motosugi

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)

抄録

Purpose: To acknowledge the facts of gadoxetate disodium-related events in Japan and to achieve better MR practice by analyzing large cohort data with various MR parameters. Materials and methods: This prospective multi-institutional study included 1993 patients (1201 men, mean age 66.4 ± 12.8 years), who received dynamic MRI with gadoxetate disodium (gadoxetate group, n = 1646) or extracellular gadolinium-based contrast agents (other-GBCAs group, n = 347) between January and November 2016. Recorded data covered adverse reactions including dyspnea, breath-hold failure during acquisition, respiratory artifacts rated with a four-point scale, and MR parameters. We compared data between the two groups in whole cohort and age-, gender-, and institution-matched subcohort using χ2 test (n = 640). Logistic regression model was used to reveal independent associates of substantial artifacts in arterial phase imaging. Results: Transient dyspnea rarely occurred in gadoxetate or other-GBCAs group (both < 1%). Gadoxetate group (vs other-GBCAs group) showed higher rates of breath-hold failure (whole cohort, 18.2% vs 7.7%, p < 0.001; subcohort, 17.6% vs 6.3%, p < 0.001) and substantial artifacts in arterial phase (7.2% vs 2.2%, p = 0.001; 7.4% vs 1.7%, p = 0.001). With single arterial phase protocol, substantial artifacts under gadoxetate were independently associated with age (odds ratio [OR] = 1.04, p < 0.001), hearing difficulty (OR = 2.92, p = 0.008), breath-hold practice required (OR = 1.61, p = 0.039), and short acquisition time (OR = 0.43, p = 0.005). Multiple arterial phase acquisition did not reduce the incident rate of substantial artifacts. Conclusion: Gadoxetate disodium was associated with breath-hold failure and substantial artifacts in arterial phase imaging, but not with dyspnea in Japan. Shorter acquisition time should be used to sustain image quality in gadoxetate disodium-enhanced arterial phase imaging. Key Points: • Gadoxetate disodium administration leads to breath-hold failure and substantial imaging artifacts in arterial phase MRI in Japan. • Contrast agent-induced dyspnea in arterial phase and adverse reactions are rare in Japan, without showing differences between gadoxetate disodium or other extracellular gadolinium-based contrast agents. • Shorter acquisition time significantly reduces gadoxetate-induced imaging artifacts in the arterial phase.

元の言語英語
ページ(範囲)281-290
ページ数10
ジャーナルEuropean Radiology
30
発行部数1
DOI
出版物ステータス出版済み - 1 1 2020

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Artifacts
Dyspnea
Japan
Odds Ratio
Contrast Media
Gadolinium
Logistic Models
gadolinium ethoxybenzyl DTPA
Hearing

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

これを引用

Gadoxetate disodium-related event during image acquisition : a prospective multi-institutional study for better MR practice. / Kromrey, Marie Luise; Hori, Masatoshi; Goshima, Satoshi; Kozaka, Kazuto; Hyodo, Tomoko; Nakamura, Yuko; Nishie, Akihiro; Tamada, Tsutomu; Shimizu, Tatsuya; Kanki, Akihiko; Motosugi, Utaroh.

:: European Radiology, 巻 30, 番号 1, 01.01.2020, p. 281-290.

研究成果: ジャーナルへの寄稿記事

Kromrey, ML, Hori, M, Goshima, S, Kozaka, K, Hyodo, T, Nakamura, Y, Nishie, A, Tamada, T, Shimizu, T, Kanki, A & Motosugi, U 2020, 'Gadoxetate disodium-related event during image acquisition: a prospective multi-institutional study for better MR practice', European Radiology, 巻. 30, 番号 1, pp. 281-290. https://doi.org/10.1007/s00330-019-06358-7
Kromrey, Marie Luise ; Hori, Masatoshi ; Goshima, Satoshi ; Kozaka, Kazuto ; Hyodo, Tomoko ; Nakamura, Yuko ; Nishie, Akihiro ; Tamada, Tsutomu ; Shimizu, Tatsuya ; Kanki, Akihiko ; Motosugi, Utaroh. / Gadoxetate disodium-related event during image acquisition : a prospective multi-institutional study for better MR practice. :: European Radiology. 2020 ; 巻 30, 番号 1. pp. 281-290.
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title = "Gadoxetate disodium-related event during image acquisition: a prospective multi-institutional study for better MR practice",
abstract = "Purpose: To acknowledge the facts of gadoxetate disodium-related events in Japan and to achieve better MR practice by analyzing large cohort data with various MR parameters. Materials and methods: This prospective multi-institutional study included 1993 patients (1201 men, mean age 66.4 ± 12.8 years), who received dynamic MRI with gadoxetate disodium (gadoxetate group, n = 1646) or extracellular gadolinium-based contrast agents (other-GBCAs group, n = 347) between January and November 2016. Recorded data covered adverse reactions including dyspnea, breath-hold failure during acquisition, respiratory artifacts rated with a four-point scale, and MR parameters. We compared data between the two groups in whole cohort and age-, gender-, and institution-matched subcohort using χ2 test (n = 640). Logistic regression model was used to reveal independent associates of substantial artifacts in arterial phase imaging. Results: Transient dyspnea rarely occurred in gadoxetate or other-GBCAs group (both < 1{\%}). Gadoxetate group (vs other-GBCAs group) showed higher rates of breath-hold failure (whole cohort, 18.2{\%} vs 7.7{\%}, p < 0.001; subcohort, 17.6{\%} vs 6.3{\%}, p < 0.001) and substantial artifacts in arterial phase (7.2{\%} vs 2.2{\%}, p = 0.001; 7.4{\%} vs 1.7{\%}, p = 0.001). With single arterial phase protocol, substantial artifacts under gadoxetate were independently associated with age (odds ratio [OR] = 1.04, p < 0.001), hearing difficulty (OR = 2.92, p = 0.008), breath-hold practice required (OR = 1.61, p = 0.039), and short acquisition time (OR = 0.43, p = 0.005). Multiple arterial phase acquisition did not reduce the incident rate of substantial artifacts. Conclusion: Gadoxetate disodium was associated with breath-hold failure and substantial artifacts in arterial phase imaging, but not with dyspnea in Japan. Shorter acquisition time should be used to sustain image quality in gadoxetate disodium-enhanced arterial phase imaging. Key Points: • Gadoxetate disodium administration leads to breath-hold failure and substantial imaging artifacts in arterial phase MRI in Japan. • Contrast agent-induced dyspnea in arterial phase and adverse reactions are rare in Japan, without showing differences between gadoxetate disodium or other extracellular gadolinium-based contrast agents. • Shorter acquisition time significantly reduces gadoxetate-induced imaging artifacts in the arterial phase.",
author = "Kromrey, {Marie Luise} and Masatoshi Hori and Satoshi Goshima and Kazuto Kozaka and Tomoko Hyodo and Yuko Nakamura and Akihiro Nishie and Tsutomu Tamada and Tatsuya Shimizu and Akihiko Kanki and Utaroh Motosugi",
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T1 - Gadoxetate disodium-related event during image acquisition

T2 - a prospective multi-institutional study for better MR practice

AU - Kromrey, Marie Luise

AU - Hori, Masatoshi

AU - Goshima, Satoshi

AU - Kozaka, Kazuto

AU - Hyodo, Tomoko

AU - Nakamura, Yuko

AU - Nishie, Akihiro

AU - Tamada, Tsutomu

AU - Shimizu, Tatsuya

AU - Kanki, Akihiko

AU - Motosugi, Utaroh

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Purpose: To acknowledge the facts of gadoxetate disodium-related events in Japan and to achieve better MR practice by analyzing large cohort data with various MR parameters. Materials and methods: This prospective multi-institutional study included 1993 patients (1201 men, mean age 66.4 ± 12.8 years), who received dynamic MRI with gadoxetate disodium (gadoxetate group, n = 1646) or extracellular gadolinium-based contrast agents (other-GBCAs group, n = 347) between January and November 2016. Recorded data covered adverse reactions including dyspnea, breath-hold failure during acquisition, respiratory artifacts rated with a four-point scale, and MR parameters. We compared data between the two groups in whole cohort and age-, gender-, and institution-matched subcohort using χ2 test (n = 640). Logistic regression model was used to reveal independent associates of substantial artifacts in arterial phase imaging. Results: Transient dyspnea rarely occurred in gadoxetate or other-GBCAs group (both < 1%). Gadoxetate group (vs other-GBCAs group) showed higher rates of breath-hold failure (whole cohort, 18.2% vs 7.7%, p < 0.001; subcohort, 17.6% vs 6.3%, p < 0.001) and substantial artifacts in arterial phase (7.2% vs 2.2%, p = 0.001; 7.4% vs 1.7%, p = 0.001). With single arterial phase protocol, substantial artifacts under gadoxetate were independently associated with age (odds ratio [OR] = 1.04, p < 0.001), hearing difficulty (OR = 2.92, p = 0.008), breath-hold practice required (OR = 1.61, p = 0.039), and short acquisition time (OR = 0.43, p = 0.005). Multiple arterial phase acquisition did not reduce the incident rate of substantial artifacts. Conclusion: Gadoxetate disodium was associated with breath-hold failure and substantial artifacts in arterial phase imaging, but not with dyspnea in Japan. Shorter acquisition time should be used to sustain image quality in gadoxetate disodium-enhanced arterial phase imaging. Key Points: • Gadoxetate disodium administration leads to breath-hold failure and substantial imaging artifacts in arterial phase MRI in Japan. • Contrast agent-induced dyspnea in arterial phase and adverse reactions are rare in Japan, without showing differences between gadoxetate disodium or other extracellular gadolinium-based contrast agents. • Shorter acquisition time significantly reduces gadoxetate-induced imaging artifacts in the arterial phase.

AB - Purpose: To acknowledge the facts of gadoxetate disodium-related events in Japan and to achieve better MR practice by analyzing large cohort data with various MR parameters. Materials and methods: This prospective multi-institutional study included 1993 patients (1201 men, mean age 66.4 ± 12.8 years), who received dynamic MRI with gadoxetate disodium (gadoxetate group, n = 1646) or extracellular gadolinium-based contrast agents (other-GBCAs group, n = 347) between January and November 2016. Recorded data covered adverse reactions including dyspnea, breath-hold failure during acquisition, respiratory artifacts rated with a four-point scale, and MR parameters. We compared data between the two groups in whole cohort and age-, gender-, and institution-matched subcohort using χ2 test (n = 640). Logistic regression model was used to reveal independent associates of substantial artifacts in arterial phase imaging. Results: Transient dyspnea rarely occurred in gadoxetate or other-GBCAs group (both < 1%). Gadoxetate group (vs other-GBCAs group) showed higher rates of breath-hold failure (whole cohort, 18.2% vs 7.7%, p < 0.001; subcohort, 17.6% vs 6.3%, p < 0.001) and substantial artifacts in arterial phase (7.2% vs 2.2%, p = 0.001; 7.4% vs 1.7%, p = 0.001). With single arterial phase protocol, substantial artifacts under gadoxetate were independently associated with age (odds ratio [OR] = 1.04, p < 0.001), hearing difficulty (OR = 2.92, p = 0.008), breath-hold practice required (OR = 1.61, p = 0.039), and short acquisition time (OR = 0.43, p = 0.005). Multiple arterial phase acquisition did not reduce the incident rate of substantial artifacts. Conclusion: Gadoxetate disodium was associated with breath-hold failure and substantial artifacts in arterial phase imaging, but not with dyspnea in Japan. Shorter acquisition time should be used to sustain image quality in gadoxetate disodium-enhanced arterial phase imaging. Key Points: • Gadoxetate disodium administration leads to breath-hold failure and substantial imaging artifacts in arterial phase MRI in Japan. • Contrast agent-induced dyspnea in arterial phase and adverse reactions are rare in Japan, without showing differences between gadoxetate disodium or other extracellular gadolinium-based contrast agents. • Shorter acquisition time significantly reduces gadoxetate-induced imaging artifacts in the arterial phase.

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