Gaining insight into the inhibition of glycoside hydrolase family 20 exo-β-N-acetylhexosaminidases using a structural approach.

Tomomi Sumida, Keith A. Stubbs, Makoto Ito, Shigeyuki Yokoyama

研究成果: Contribution to journalArticle査読

24 被引用数 (Scopus)

抄録

One useful methodology that has been used to give insight into how chemically synthesized inhibitors bind to enzymes and the reasons underlying their potency is crystallographic studies of inhibitor-enzyme complexes. Presented here is the X-ray structural analysis of a representative family 20 exo-β-N-acetylhexosaminidase in complex with various known classes of inhibitor of these types of enzymes, which highlights how different inhibitor classes can inhibit the same enzyme. This study will aid in the future development of inhibitors of not only exo-β-N-acetylhexosaminidases but also other types of glycoside hydrolases.

本文言語英語
ページ(範囲)2607-2612
ページ数6
ジャーナルOrganic and Biomolecular Chemistry
10
13
DOI
出版ステータス出版済み - 4 7 2012

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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