Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy

Victor L.J.L. Thijssen, Ruben Postel, Ricardo J.M.G.E. Brandwijk, Ruud P.M. Dings, Irina Nesmelova, Sietske Satijn, Nicole Verhofstad, Yusaku Nakabeppu, Linda G. Baum, Jeroen Bakkers, Kevin H. Mayo, Françoise Poirier, Arjan W. Griffioen

研究成果: ジャーナルへの寄稿学術誌査読

379 被引用数 (Scopus)

抄録

We describe that galectin-1 (gal-1) is a receptor for the angiogenesis inhibitor anginex, and that the protein is crucial for tumor angiogenesis. gal-1 is overexpressed in endothelial cells of different human tumors. Expression knockdown in cultured endothelial cells inhibits cell proliferation and migration. The importance of gal-1 in angiogenesis is illustrated in the zebrafish model, where expression knockdown results in impaired vascular guidance and growth of dysfunctional vessels. The role of gal-1 in tumor angiogenesis is demonstrated in gal-1-null mice, in which tumor growth is markedly impaired because of insufficient tumor angiogenesis. Furthermore, tumor growth in gal-1-null mice no longer responds to antiangiogenesis treatment by anginex. Thus, gal-1 regulates tumor angiogenesis and is a target for angiostatic cancer therapy.

本文言語英語
ページ(範囲)15975-15980
ページ数6
ジャーナルProceedings of the National Academy of Sciences of the United States of America
103
43
DOI
出版ステータス出版済み - 10月 24 2006

!!!All Science Journal Classification (ASJC) codes

  • 一般

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