Galectin-3 expression is a potent prognostic marker in colorectal cancer

Kazuya Endo, Shunji Kohnoe, Eiji Tsujita, Akihiro Watanabe, Hideaki Nakashima, Hideo Baba, Yoshihiko Maehara

研究成果: ジャーナルへの寄稿学術誌査読

70 被引用数 (Scopus)

抄録

Background: Galectin-3 is a β-galactoside-binding protein whose expression has been correlated with progression and metastasis in colon cancer. It is expressed at elevated levels in a variety of neoplastic cells. The current study was designed to investigate, by clinicopathological analysis, the relationship between prognosis and galectin-3 expression, in colorectal cancer. Patients and Methods: Galectin-3 expression was evaluated using immunohistochemical staining in 121 consecutive patients with colorectal cancer. The relationship between galectin-3 expression and clinicopathological factors was analyzed. Results: Galectin-3-positive expression was detected in 79 patients (65%). The incidence of lymph node and distant metastasis in galectin 3-positive cancer was significantly higher than that in galectin-3-negative cases (p=0.0007 and p=0.014, respectively). Furthermore, cancers with galectin-3-positive expression revealed frequent venous invasion (p=0.005) and lymphatic permeation (p=0.041), larger size (p=0.016) and deeper invasion to wall(p=0.01) than in galectin-3-negative cases. While univariate analysis showed that survival in patients with galectin-3-positive expression was significantly poorer than in galectin-3-negative cases (p=0.0027), galectin-3 expression was a prognostic factor independent of Dukes' stage and lymph node metastasis by multivariate analysis. Conclusion: We propose that galectin-3 expression is an independent factor for prognosis in colorectal cancer.

本文言語英語
ページ(範囲)3117-3122
ページ数6
ジャーナルAnticancer research
25
4
出版ステータス出版済み - 7月 2005

!!!All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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