Ganoderol B: A potent α-glucosidase inhibitor isolated from the fruiting body of Ganoderma lucidum

Sri Fatmawati, Kuniyoshi Shimizu, Ryuichiro Kondo

研究成果: ジャーナルへの寄稿学術誌査読

87 被引用数 (Scopus)

抄録

α-Glucosidase inhibitor has considerable potential as a diabetes mellitus type 2 drug because it prevents the digestion of carbohydrates. The search for the constituents reducing α-glucosidase activity led to the finding of active compounds in the fruiting body of Ganoderma lucidum. The CHCl 3 extract of the fruiting body of G. lucidum was found to show inhibitory activity on α-glucosidase in vitro. The neutral fraction, with an IC 50 of 88.7 μg/ml, had stronger inhibition than a positive control, acarbose, with an IC 50 of 336.7 μg/ml (521.5 μM). The neutral fraction was subjected to silica gel column chromatography and repeated p-HPLC to provide an active compound, (3β,24E)-lanosta-7,9(11),24-trien-3, 26-diol (ganoderol B). It was found to have high α-glucosidase inhibition, with an IC 50 of 48.5 μg/ml (119.8 μM).

本文言語英語
ページ(範囲)1053-1055
ページ数3
ジャーナルPhytomedicine
18
12
DOI
出版ステータス出版済み - 9月 15 2011

!!!All Science Journal Classification (ASJC) codes

  • 分子医療
  • 薬理学
  • 薬科学
  • 創薬
  • 補完代替医療

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