TY - JOUR
T1 - Gender differences in prognosis after esophagectomy for esophageal cancer
AU - Morita, Masaru
AU - Otsu, Hajime
AU - Kawano, Hiroyuki
AU - Kasagi, Yuta
AU - Kimura, Yasue
AU - Saeki, Hiroshi
AU - Ando, Koji
AU - Ida, Satoshi
AU - Oki, Eiji
AU - Tokunaga, Eriko
AU - Ikeda, Tetsuo
AU - Kusumoto, Tetsuya
AU - Maehara, Yoshihiko
N1 - Funding Information:
We thank Professor Brian Quinn for assisting with the preparation of this manuscript. This work was supported in part by a Grant-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan.
PY - 2014/3
Y1 - 2014/3
N2 - Purpose: The purpose of this study was to clarify the gender differences in the prognosis, as well as mortality and morbidity, of patients who have undergone esophagectomy for esophageal cancer. Methods: The clinical results of esophagectomy were compared between 975 male and 156 female patients with esophageal cancer. Results: The male to female ratios of cervical and thoracic esophageal cancer were 1.87 and 7.38, respectively (P < 0.01). The incidence of preoperative comorbidities was 32.4 and 17.4 %, respectively, and the rates of both tobacco and alcohol abuse were significantly lower in the females than in the males. The mortality rate was lower in the females (3.8 %) than in the males (5.7 %), although the differences were not significant. The overall survival was significantly better in the female than in the male patients (P = 0.039). The 5- and 10-year overall survival rates were 32.6 and 20.5 % in the males and 39.5 and 32.5 % in the females, respectively. A multivariate analysis revealed gender to be an independent prognostic factor. However, no significant differences were recognized in disease-specific survival. Conclusions: These results suggest that the prognosis of females with esophageal cancer is better than that of males after esophagectomy, most likely due to multiple clinical factors, such as a more favorable lifestyle and general status.
AB - Purpose: The purpose of this study was to clarify the gender differences in the prognosis, as well as mortality and morbidity, of patients who have undergone esophagectomy for esophageal cancer. Methods: The clinical results of esophagectomy were compared between 975 male and 156 female patients with esophageal cancer. Results: The male to female ratios of cervical and thoracic esophageal cancer were 1.87 and 7.38, respectively (P < 0.01). The incidence of preoperative comorbidities was 32.4 and 17.4 %, respectively, and the rates of both tobacco and alcohol abuse were significantly lower in the females than in the males. The mortality rate was lower in the females (3.8 %) than in the males (5.7 %), although the differences were not significant. The overall survival was significantly better in the female than in the male patients (P = 0.039). The 5- and 10-year overall survival rates were 32.6 and 20.5 % in the males and 39.5 and 32.5 % in the females, respectively. A multivariate analysis revealed gender to be an independent prognostic factor. However, no significant differences were recognized in disease-specific survival. Conclusions: These results suggest that the prognosis of females with esophageal cancer is better than that of males after esophagectomy, most likely due to multiple clinical factors, such as a more favorable lifestyle and general status.
UR - http://www.scopus.com/inward/record.url?scp=84896715557&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84896715557&partnerID=8YFLogxK
U2 - 10.1007/s00595-013-0573-x
DO - 10.1007/s00595-013-0573-x
M3 - Article
C2 - 23563736
AN - SCOPUS:84896715557
VL - 44
SP - 505
EP - 512
JO - Surgery Today
JF - Surgery Today
SN - 0941-1291
IS - 3
ER -