TY - JOUR
T1 - Gene and protein expressions of type I collagen are regulated tissue-specifically in rat hyaline cartilages in vivo
AU - Sasano, Yasuyuki
AU - Takahashi, Ichiro
AU - Zhu, Jing Xu
AU - Ohtani, Haruo
AU - Mizoguchi, Itaru
AU - Kagayama, Manabu
PY - 2001/12/1
Y1 - 2001/12/1
N2 - The present study was designed to investigate how rat hyaline cartilages at various sites in vivo express the gene and protein of type I collagen using in situ hybridization and immuno-histochemistry. The gene of pro alpha 1(I) collagen was expressed by chondrocytes in articular cartilage, and the protein of type I collagen was identified in the cartilage matrix. In contrast, growth plate cartilage expressed the gene of pro alpha 1(I) collagen, but no protein of type I collagen. Neither gene nor protein of type I collagen was expressed in cartilages of trachea and nasal septum. The present study suggested that expression of type I collagen in hyaline cartilages may be regulated tissue-specifically at gene and/or protein levels.
AB - The present study was designed to investigate how rat hyaline cartilages at various sites in vivo express the gene and protein of type I collagen using in situ hybridization and immuno-histochemistry. The gene of pro alpha 1(I) collagen was expressed by chondrocytes in articular cartilage, and the protein of type I collagen was identified in the cartilage matrix. In contrast, growth plate cartilage expressed the gene of pro alpha 1(I) collagen, but no protein of type I collagen. Neither gene nor protein of type I collagen was expressed in cartilages of trachea and nasal septum. The present study suggested that expression of type I collagen in hyaline cartilages may be regulated tissue-specifically at gene and/or protein levels.
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U2 - 10.1076/ejom.39.3.149.4675
DO - 10.1076/ejom.39.3.149.4675
M3 - Article
C2 - 11910533
AN - SCOPUS:0035727925
SN - 0924-3860
VL - 39
SP - 149
EP - 154
JO - European Journal of Morphology
JF - European Journal of Morphology
IS - 3
ER -