Gene Polymorphism-related Individual and Interracial Differences in the Outcomes of Androgen Deprivation Therapy for Prostate Cancer

Naohiro Fujimoto, Masaki Shiota, Ikko Tomisaki, Akinori Minato

研究成果: Contribution to journalReview article査読

10 被引用数 (Scopus)

抄録

Among patients with prostate cancer, the prognosis after androgen deprivation therapy differs significantly among individuals and among races; however, the reasons underlying these differences are poorly understood. Several single nucleotide polymorphisms in genes associated with prostate cancer progression or castration resistance might serve as the host factor that influences prognosis and, thus, accounts for these individual and racial gaps in treatment outcomes. Accordingly, single nucleotide polymorphisms associated with treatment outcomes could be used as predictive and/or prognostic biomarkers for patient stratification and to identify personalized treatment and follow-up protocols. The present review has summarized the genetic polymorphisms that have been reported to associate with androgen deprivation therapy outcomes among patients with prostate cancer and compared the allele frequencies among different ethnic groups.

本文言語英語
ページ(範囲)337-342
ページ数6
ジャーナルClinical Genitourinary Cancer
15
3
DOI
出版ステータス出版済み - 6 2017

All Science Journal Classification (ASJC) codes

  • Oncology
  • Urology

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