Gene regulation of filaggrin and other skin barrier proteins via aryl hydrocarbon receptor

Masutaka Furue, Gaku Tsuji, Chikage Mitoma, Takeshi Nakahara, Takahito Chiba, Saori Morino-Koga, Hiroshi Uchi

研究成果: ジャーナルへの寄稿評論記事

40 引用 (Scopus)

抜粋

Aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that binds to structurally diverse chemicals including dioxins, coal tar, flavonoids and tryptophan photoproducts. Upon ligation, cytoplasmic AHR translocates to the nucleus, heterodimerizes with aryl hydrocarbon receptor nuclear translocator and mediates numerous biological effects by inducing the transcription of various AHR-responsive genes such as epidermal barrier proteins. The activation of AHR usually generates oxidative stress. However, AHR also mediates antioxidant signaling by a plethora of ligands via nuclear factor-erythroid 2-related factor-2. Both oxidative and antioxidant ligands upregulate the expression of the filaggrin gene. We review the role of AHR signaling in the gene regulation of epidermal barrier proteins.

元の言語英語
ページ(範囲)83-88
ページ数6
ジャーナルJournal of Dermatological Science
80
発行部数2
DOI
出版物ステータス出版済み - 11 1 2015

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Dermatology

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