Generalized melanosis in metastatic malignant melanoma: The possible role of DOPAquinone metabolites

K. Tsukamoto, M. Furue, Y. Sato, O. Takayama, R. Akasu, N. Ohtake, K. Wakamatsu, S. Ito, K. Tamaki, S. Shimada

研究成果: Contribution to journalArticle査読

17 被引用数 (Scopus)

抄録

Generalized melanosis occurs very rarely as a complication of malignant melanoma, and the pathogenesis of this condition is still unclear. Histological examination of pigmented skin and measurements of the DOPAquinone metabolites 5-S-cysteinyldopa (5-S-CD) and 6-hydroxy-5-methoxyindole-2-carboxylic acid (6H5MI2C) in the patient's serum and urine were carried out. Histological examination revealed basal hyperpigmentation, discrete melanoma cells and melanophages around the blood vessels and an unusual melanin deposition within collagen bundles in the dermis. The levels of 5-S-CD and 6H5MI2C were dramatically increased both in the patient's serum and urine. The deposition of DOPAquinone metabolites secreted by the melanoma cells may contribute to the unusual melanin deposition within collagen bundles in the affected dermis.

本文言語英語
ページ(範囲)338-342
ページ数5
ジャーナルDermatology
197
4
DOI
出版ステータス出版済み - 12 1 1998

All Science Journal Classification (ASJC) codes

  • 皮膚病学

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