Generation of Robust Left-Right Asymmetry in the Mouse Embryo Requires a Self-Enhancement and Lateral-Inhibition System

Tetsuya Nakamura, Naoki Mine, Etsushi Nakaguchi, Atsushi Mochizuki, Masamichi Yamamoto, Kenta Yashiro, Chikara Meno, Hiroshi Hamada

研究成果: ジャーナルへの寄稿記事

142 引用 (Scopus)

抄録

The bilateral symmetry of the mouse embryo is broken by leftward fluid flow in the node. However, it is unclear how this directional flow is then translated into the robust, left side-specific Nodal gene expression that determines and coordinates left-right situs throughout the embryo. While manipulating Nodal and Lefty gene expression, we have observed phenomena that are indicative of the involvement of a self-enhancement and lateral-inhibition (SELI) system. We constructed a mathematical SELI model that not only simulates, but also predicts, experimental data. As predicted by the model, Nodal expression initiates even on the right side. These results indicate that directional flow represents an initial small difference between the left and right sides of the embryo, but is insufficient to determine embryonic situs. Nodal and Lefty are deployed as a SELI system required to amplify this initial bias and convert it into robust asymmetry.

元の言語英語
ページ(範囲)495-504
ページ数10
ジャーナルDevelopmental Cell
11
発行部数4
DOI
出版物ステータス出版済み - 10 1 2006
外部発表Yes

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Gene expression
Embryonic Structures
Gene Expression
Flow of fluids

All Science Journal Classification (ASJC) codes

  • Developmental Biology

これを引用

Nakamura, T., Mine, N., Nakaguchi, E., Mochizuki, A., Yamamoto, M., Yashiro, K., ... Hamada, H. (2006). Generation of Robust Left-Right Asymmetry in the Mouse Embryo Requires a Self-Enhancement and Lateral-Inhibition System. Developmental Cell, 11(4), 495-504. https://doi.org/10.1016/j.devcel.2006.08.002

Generation of Robust Left-Right Asymmetry in the Mouse Embryo Requires a Self-Enhancement and Lateral-Inhibition System. / Nakamura, Tetsuya; Mine, Naoki; Nakaguchi, Etsushi; Mochizuki, Atsushi; Yamamoto, Masamichi; Yashiro, Kenta; Meno, Chikara; Hamada, Hiroshi.

:: Developmental Cell, 巻 11, 番号 4, 01.10.2006, p. 495-504.

研究成果: ジャーナルへの寄稿記事

Nakamura, T, Mine, N, Nakaguchi, E, Mochizuki, A, Yamamoto, M, Yashiro, K, Meno, C & Hamada, H 2006, 'Generation of Robust Left-Right Asymmetry in the Mouse Embryo Requires a Self-Enhancement and Lateral-Inhibition System', Developmental Cell, 巻. 11, 番号 4, pp. 495-504. https://doi.org/10.1016/j.devcel.2006.08.002
Nakamura, Tetsuya ; Mine, Naoki ; Nakaguchi, Etsushi ; Mochizuki, Atsushi ; Yamamoto, Masamichi ; Yashiro, Kenta ; Meno, Chikara ; Hamada, Hiroshi. / Generation of Robust Left-Right Asymmetry in the Mouse Embryo Requires a Self-Enhancement and Lateral-Inhibition System. :: Developmental Cell. 2006 ; 巻 11, 番号 4. pp. 495-504.
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