Generation of RORγt + Antigen-Specific T Regulatory 17 Cells from Foxp3 + Precursors in Autoimmunity

Byung Seok Kim, Huiping Lu, Kenji Ichiyama, Xiang Chen, Yi Bing Zhang, Nipun A. Mistry, Kentaro Tanaka, Young hee Lee, Roza Nurieva, Li Zhang, Xuexian Yang, Yeonseok Chung, Wei Jin, Seon Hee Chang, Chen Dong

研究成果: ジャーナルへの寄稿記事

25 引用 (Scopus)

抄録

Th17 cells are potent mediators in autoimmune diseases, and RORγt is required for their development. Recent studies have shown that RORγt + Treg cells in the gut regulate intestinal inflammation by inhibiting effector T cell function. In the current study, we report that RORγt + Treg cells were also found in lymph nodes following immunization. Not only distinct from intestinal RORγt + Treg cells in their transcriptomes, peripheral RORγt + Treg cells were derived from Foxp3 + thymic Treg cells in an antigen-specific manner. Development of these RORγt + Treg cells, coined T regulatory 17 (Tr17) cells, depended on IL-6/Stat3 signaling. Tr17 cells showed suppressive activity against antigen-specific effector T cells in vitro. In addition, Tr17 cells efficiently inhibited myelin-specific Th17-cell-mediated CNS auto-inflammation in a passive EAE model. Collectively, our study demonstrates that Tr17 cells are effector Treg cells that potentially restrict autoimmunity. Kim et al. find that RORγt + Foxp3 + T regulatory 17 (Tr17) cells are induced in lymph nodes after immunization. Tr17 cells are generated from thymic Treg cells in an antigen-specific manner through Stat3 signaling. Their data suggest that Tr17 cells represent antigen-specific effector Treg cells that can regulate Th17-cell-dependent autoimmunity.

元の言語英語
ページ(範囲)195-207
ページ数13
ジャーナルCell Reports
21
発行部数1
DOI
出版物ステータス出版済み - 10 3 2017

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Regulatory T-Lymphocytes
Autoimmunity
Immunization
Antigens
T-cells
Th17 Cells
Interleukin-6
Lymph Nodes
Inflammation
T-Lymphocytes
Myelin Sheath
Transcriptome
Autoimmune Diseases

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

これを引用

Kim, B. S., Lu, H., Ichiyama, K., Chen, X., Zhang, Y. B., Mistry, N. A., ... Dong, C. (2017). Generation of RORγt + Antigen-Specific T Regulatory 17 Cells from Foxp3 + Precursors in Autoimmunity Cell Reports, 21(1), 195-207. https://doi.org/10.1016/j.celrep.2017.09.021

Generation of RORγt + Antigen-Specific T Regulatory 17 Cells from Foxp3 + Precursors in Autoimmunity . / Kim, Byung Seok; Lu, Huiping; Ichiyama, Kenji; Chen, Xiang; Zhang, Yi Bing; Mistry, Nipun A.; Tanaka, Kentaro; Lee, Young hee; Nurieva, Roza; Zhang, Li; Yang, Xuexian; Chung, Yeonseok; Jin, Wei; Chang, Seon Hee; Dong, Chen.

:: Cell Reports, 巻 21, 番号 1, 03.10.2017, p. 195-207.

研究成果: ジャーナルへの寄稿記事

Kim, BS, Lu, H, Ichiyama, K, Chen, X, Zhang, YB, Mistry, NA, Tanaka, K, Lee, YH, Nurieva, R, Zhang, L, Yang, X, Chung, Y, Jin, W, Chang, SH & Dong, C 2017, ' Generation of RORγt + Antigen-Specific T Regulatory 17 Cells from Foxp3 + Precursors in Autoimmunity ', Cell Reports, 巻. 21, 番号 1, pp. 195-207. https://doi.org/10.1016/j.celrep.2017.09.021
Kim, Byung Seok ; Lu, Huiping ; Ichiyama, Kenji ; Chen, Xiang ; Zhang, Yi Bing ; Mistry, Nipun A. ; Tanaka, Kentaro ; Lee, Young hee ; Nurieva, Roza ; Zhang, Li ; Yang, Xuexian ; Chung, Yeonseok ; Jin, Wei ; Chang, Seon Hee ; Dong, Chen. / Generation of RORγt + Antigen-Specific T Regulatory 17 Cells from Foxp3 + Precursors in Autoimmunity :: Cell Reports. 2017 ; 巻 21, 番号 1. pp. 195-207.
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abstract = "Th17 cells are potent mediators in autoimmune diseases, and RORγt is required for their development. Recent studies have shown that RORγt + Treg cells in the gut regulate intestinal inflammation by inhibiting effector T cell function. In the current study, we report that RORγt + Treg cells were also found in lymph nodes following immunization. Not only distinct from intestinal RORγt + Treg cells in their transcriptomes, peripheral RORγt + Treg cells were derived from Foxp3 + thymic Treg cells in an antigen-specific manner. Development of these RORγt + Treg cells, coined T regulatory 17 (Tr17) cells, depended on IL-6/Stat3 signaling. Tr17 cells showed suppressive activity against antigen-specific effector T cells in vitro. In addition, Tr17 cells efficiently inhibited myelin-specific Th17-cell-mediated CNS auto-inflammation in a passive EAE model. Collectively, our study demonstrates that Tr17 cells are effector Treg cells that potentially restrict autoimmunity. Kim et al. find that RORγt + Foxp3 + T regulatory 17 (Tr17) cells are induced in lymph nodes after immunization. Tr17 cells are generated from thymic Treg cells in an antigen-specific manner through Stat3 signaling. Their data suggest that Tr17 cells represent antigen-specific effector Treg cells that can regulate Th17-cell-dependent autoimmunity.",
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AU - Zhang, Yi Bing

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AU - Jin, Wei

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AU - Dong, Chen

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