Genetic and environmental backgrounds responsible for the changes in the phenotype of MS in Japanese subjects

研究成果: ジャーナルへの寄稿評論記事

6 引用 (Scopus)

抄録

There are two distinct phenotypes of multiple sclerosis (MS) in Asians, manifesting as opticospinal (OSMS) and conventional (CMS) forms. In Japan, the results of four nationwide surveys of MS conducted between 1972 and 2004 have revealed a four-fold increase in the estimated number of clinically definite MS patients in 2003 compared with 1972; a shift in the peak age at onset from the early 30s in 1989 to the early 20s in 2003; a successive proportional decrease in optic-spinal involvement in clinically definite MS patients; an increase in the number of CMS patients with Barkhof brain lesions with advancing birth year and a decrease in the number of OSMS patients with LESCLs. These findings suggest that MS phenotypes are drastically altered by environmental factors such as latitude and "Westernization". Helicobacter pylori infection rates, reflecting sanitary conditions in infancy, are significantly different between CMS and OSMS patients. Both phenotypes show distinct HLA class II gene associations. Therefore, changes in environmental factors may have differentially influenced susceptibility to each disease subtype, given that disease susceptibility is only partly genetically determined.

元の言語英語
ページ(範囲)188-195
ページ数8
ジャーナルMultiple Sclerosis and Related Disorders
1
発行部数4
DOI
出版物ステータス出版済み - 10 1 2012

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Multiple Sclerosis
Phenotype
MHC Class II Genes
Disease Susceptibility
Helicobacter Infections
Age of Onset
Helicobacter pylori
Japan
Genetic Background
Parturition
Brain

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

これを引用

Genetic and environmental backgrounds responsible for the changes in the phenotype of MS in Japanese subjects. / Kira, Jun-Ichi.

:: Multiple Sclerosis and Related Disorders, 巻 1, 番号 4, 01.10.2012, p. 188-195.

研究成果: ジャーナルへの寄稿評論記事

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AB - There are two distinct phenotypes of multiple sclerosis (MS) in Asians, manifesting as opticospinal (OSMS) and conventional (CMS) forms. In Japan, the results of four nationwide surveys of MS conducted between 1972 and 2004 have revealed a four-fold increase in the estimated number of clinically definite MS patients in 2003 compared with 1972; a shift in the peak age at onset from the early 30s in 1989 to the early 20s in 2003; a successive proportional decrease in optic-spinal involvement in clinically definite MS patients; an increase in the number of CMS patients with Barkhof brain lesions with advancing birth year and a decrease in the number of OSMS patients with LESCLs. These findings suggest that MS phenotypes are drastically altered by environmental factors such as latitude and "Westernization". Helicobacter pylori infection rates, reflecting sanitary conditions in infancy, are significantly different between CMS and OSMS patients. Both phenotypes show distinct HLA class II gene associations. Therefore, changes in environmental factors may have differentially influenced susceptibility to each disease subtype, given that disease susceptibility is only partly genetically determined.

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