Genetic and Epigenetic Regulators of Pluripotency

M. Azim Surani, Katsuhiko Hayashi, Petra Hajkova

研究成果: Contribution to journalReview article査読

494 被引用数 (Scopus)

抄録

Genetic and epigenetic mechanisms regulate the transition from the totipotent zygote to pluripotent primitive ectoderm cells in the inner cell mass of mouse blastocysts. These pluripotent cells can be propagated indefinitely in vitro, underpinned by a unique epigenetic state. Following implantation of the blastocyst, diverse epigenetic modifiers control differentiation of pluripotent epiblast cells into somatic cells, while specification of germ cells requires repression of the somatic program. Regenerating totipotency during development of germ cells entails re-expression of pluripotency-specific genes and extensive erasure of epigenetic modifications. Increasing knowledge of key underlying mechanisms heightens prospects for creating pluripotent cells directly from adult somatic cells.

本文言語英語
ページ(範囲)747-762
ページ数16
ジャーナルCell
128
4
DOI
出版ステータス出版済み - 2 23 2007
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学、遺伝学、分子生物学(全般)

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