Genetic characterization of Drosophila RBP-Jx (Suppressor of Hairless) as a neurogenic gene in adult PNS development

Takahisa Furukawa, Kumiko Tamura, Masashi Kawaichi, Tasuku Honjo, Kenichi Kimura, Yoshitaka Kobayakawa, Teiichi Tanimura

研究成果: Contribution to journalArticle

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抜粋

Drosophila RBP-Jx is a novel sequence-specific DNA binding protein encompassing the integrase motif which is highly conserved in various organisms. Its gene has been shown to be identical to Suppressor of Hairless which regulates adult peripheral nervous system (PNS) development. To elucidate the precise function of the RBF-Jx protein in adult PNS development, we analyzed transgenic flies that misexpress the RBP-Jx protein. Such studies have shown that UBF-Jx regulates PNS cell fate in at least two steps: commitment to sensory mother cell by lateral inhibition and terminal differentiation into the socket and shaft cells. Taken together with analysis of phenotypes of Suppressor of Hairless mutants, RBP-Jx shows the synergistic activity with neurogenic genes.

元の言語英語
ページ(範囲)701-711
ページ数11
ジャーナルJapanese Journal of Genetics
69
発行部数6
DOI
出版物ステータス出版済み - 1 1 1994

All Science Journal Classification (ASJC) codes

  • Genetics

フィンガープリント Genetic characterization of Drosophila RBP-Jx (Suppressor of Hairless) as a neurogenic gene in adult PNS development' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Furukawa, T., Tamura, K., Kawaichi, M., Honjo, T., Kimura, K., Kobayakawa, Y., & Tanimura, T. (1994). Genetic characterization of Drosophila RBP-Jx (Suppressor of Hairless) as a neurogenic gene in adult PNS development. Japanese Journal of Genetics, 69(6), 701-711. https://doi.org/10.1266/jjg.69.701