Genetic determinants of lung cancer short-term survival: The role of glutathione-related genes

Ping Yang, Akira Yokomizo, Henry D. Tazelaar, Randolph S. Marks, Timothy G. Lesnick, Daniel L. Miller, Jeff A. Sloan, Eric S. Edell, Rebecca L. Meyer, James Jett, Wanguo Liu

研究成果: ジャーナルへの寄稿学術誌査読

44 被引用数 (Scopus)

抄録

Purpose: Survival of lung cancer patients has been dismal. Glutathione enzymes are directly involved in the metabolism of platinum compounds, a group of important chemotherapeutic drugs in cancer treatment. We tested the hypothesis that genes encoding glutathione enzymes may predict lung cancer short-term survival. Methods: We studied DNA polymorphisms of 250 primary lung cancer patients at four glutathione-related loci: GSTP1, GSTM1, GSTT1 and γ-GCS that encode glutathione-S-transferase-π, glutathione-S-transferase-μ, glutathione-S-transferase-θ, and γ-glutamylcysteine synthetase, respectively. Pearson's χ2-square tests, Kaplan-Meier survival curves, log rank tests, and Cox regression models were applied in the analysis. Results: There were 150 (60%) men and 100 (40%) women in this study. Seventeen percent of the patients had never smoked cigarettes, and 61% had stopped smoking at least 6 months prior to their lung cancer diagnosis. Among never smokers, those with null (N) or low (L) genotype experienced a better 1-year-survival rate than those with a positive (P) or high (H) genotype. Patients with P or H at two loci (PP or PH) were compared with patients with N or L at one or both loci (other). Among never smokers, 1-year-survival rates were 60-78% for patients with PP or PH genotypes compared with 89-100% for other types. The survival advantage was greater among advanced-stage patients who were NL or NN than low-stage patients. Similar results were not observed among smokers. Conclusions: Glutathione-related genes may determine lung cancer survival. Our results, if confirmed, would suggest new directions to enhance cancer treatment, and provide easily measurable markers for clinicians to plan patient-specific therapy.

本文言語英語
ページ(範囲)221-229
ページ数9
ジャーナルLung Cancer
35
3
DOI
出版ステータス出版済み - 2002

!!!All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 呼吸器内科
  • 癌研究

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