Genetic diversity of enterohemorrhagic Escherichia coli

Makoto Ohnishi, Tetsuya Hayashi

研究成果: Contribution to journalReview article査読

2 被引用数 (Scopus)

抄録

Enterohemorrhagic Escherichia coli(EHEC) causes diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome. Genomic comparison of an EHEC O157: H7 strain isolated from the Sakai outbreak and a benign laboratory strain K-12 revealed that acquisition of a large amount of foreign DNA has promoted the genetic diversification of E. coli strains. In the emergence of O157: H7, bacteriophages, in particular, played an important role. EHEC are a group of strains with several serotypes, each belonging to different E. coli lineages. Even in an O157 lineage, significant phenotypic and genetic heterogeneities are observed. Recent knowledge on the significance and the generating mechanism of such heterogeneity in EHEC strains are summarized.

本文言語英語
ページ(範囲)1077-1082
ページ数6
ジャーナルNippon rinsho. Japanese journal of clinical medicine
60
6
出版ステータス出版済み - 6 2002
外部発表はい

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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