Genetic polymorphisms of CYP2E1 and risk of colorectal cancer: The fukuoka colorectal cancer study

Makiko Morita, Loïc Le Marchand, Suminori Kono, Guang Yin, Kengo Toyomura, Jun Nagano, Tetsuya Mizoue, Ryuichi Mibu, Masao Tanaka, Yoshihiro Kakeji, Yoshihiko Maehara, Takeshi Okamura, Koji Ikejiri, Kitaroh Futami, Takafumi Maekawa, Yohichi Yasunami, Kenji Takenaka, Hitoshi Ichimiya, Nobutoshi Imaizumi

研究成果: Contribution to journalArticle査読

38 被引用数 (Scopus)

抄録

Cytochrome P450 2E1 (CYP2E1) is involved in the metabolic activation of a wide variety of potential carcinogens, and functional polymorphisms in the CYP2E1 gene have been investigated in relation to colorectal cancer. We examined the relation of the CYP2E1 RsaI and 96-bp insertion polymorphisms to colorectal cancer risk and the interaction between these polymorphisms and some lifestyle risk factors. Subjects were 685 incident cases of colorectal cancer and 778 community controls. Statistical adjustment was made for alcohol use, body mass index, physical activity, and other factors. The RsaI c2 allele was associated with a decreased risk of rectal cancer [adjusted odds ratio for at least one c2 allele, 0.71; 95% confidence interval (95% CI), 0.53-0.95], and an increased risk of rectal cancer was observed among individuals having one or two 96-bp insertion alleles (adjusted odds ratio, 1.40; 95% CI, 1.06-1.85). Individuals with two 96-bp insertion alleles showed a 2.28-fold increase in colon cancer risk (95% CI, 1.29-4.01). The two polymorphisms were in almost complete linkage disequilibrium (D′ = 0.94). A positive association between alcohol intake and colorectal cancer was observed only in individuals without RsaI c2 allele (Ptrend = 0.03) or in those without 96-bp insertion allele (P trend = 0.009). Colon cancer risk was increased in relation to red meat intake only in individuals having one or two 96-bp insertion alleles (Pinteraction = 0.03). The present study suggests that variation in activity and inducibility of CYP2E1, in relation to alcohol or red meat intake, contributes to the development of colorectal cancer.

本文言語英語
ページ(範囲)235-241
ページ数7
ジャーナルCancer Epidemiology Biomarkers and Prevention
18
1
DOI
出版ステータス出版済み - 1 2009

All Science Journal Classification (ASJC) codes

  • 疫学
  • 腫瘍学

フィンガープリント

「Genetic polymorphisms of CYP2E1 and risk of colorectal cancer: The fukuoka colorectal cancer study」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル